The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
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The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive. / Falskov, Britt; Hermann, Thomas Steffen; Rask-Madsen, Christian; Major-Pedersen, Atheline; Christiansen, Buris; Raunsø, Jakob; Køber, Lars; Torp-Pedersen, Christian; Dominguez, Helena.
I: Vascular Health and Risk Management (Online), Bind 7, 2011, s. 771-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
AU - Falskov, Britt
AU - Hermann, Thomas Steffen
AU - Rask-Madsen, Christian
AU - Major-Pedersen, Atheline
AU - Christiansen, Buris
AU - Raunsø, Jakob
AU - Køber, Lars
AU - Torp-Pedersen, Christian
AU - Dominguez, Helena
PY - 2011
Y1 - 2011
N2 - AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.METHODS: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.RESULTS: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% ± 6.16%, 23.50% ± 8.32%, and 22.29% ± 10.77% at the three doses respectively, compared to the healthy control group 45.96% ± 11.56%, 67.40% ± 18.11% and 84.57% ± 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% ± 7.81%, -2.35% ± 11.76%, and 5.82% ± 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).CONCLUSION: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.
AB - AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.METHODS: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.RESULTS: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% ± 6.16%, 23.50% ± 8.32%, and 22.29% ± 10.77% at the three doses respectively, compared to the healthy control group 45.96% ± 11.56%, 67.40% ± 18.11% and 84.57% ± 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% ± 7.81%, -2.35% ± 11.76%, and 5.82% ± 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).CONCLUSION: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.
KW - Aged
KW - Diabetes Mellitus, Type 2
KW - Endothelium, Vascular
KW - Female
KW - Forearm
KW - Glucose
KW - Heart Failure
KW - Humans
KW - Hypoglycemic Agents
KW - Infusions, Intra-Arterial
KW - Insulin
KW - Insulin Resistance
KW - Male
KW - Middle Aged
KW - Muscle, Skeletal
KW - Plethysmography
KW - Regional Blood Flow
KW - Serotonin
KW - Serotonin Receptor Agonists
KW - Vasodilation
U2 - 10.2147/VHRM.S25724
DO - 10.2147/VHRM.S25724
M3 - Journal article
C2 - 22241951
VL - 7
SP - 771
EP - 776
JO - Vascular Health and Risk Management
JF - Vascular Health and Risk Management
SN - 1176-6344
ER -
ID: 157441124