The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. / Bang, U.; Viby‐Mogensen, J.; Wirén, J. E.; Skovgaard, L. Theil.

I: Acta Anaesthesiologica Scandinavica Supplementum, Bind 34, Nr. 7, 10.1990, s. 596-599.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bang, U, Viby‐Mogensen, J, Wirén, JE & Skovgaard, LT 1990, 'The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients', Acta Anaesthesiologica Scandinavica Supplementum, bind 34, nr. 7, s. 596-599. https://doi.org/10.1111/j.1399-6576.1990.tb03152.x

APA

Bang, U., Viby‐Mogensen, J., Wirén, J. E., & Skovgaard, L. T. (1990). The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. Acta Anaesthesiologica Scandinavica Supplementum, 34(7), 596-599. https://doi.org/10.1111/j.1399-6576.1990.tb03152.x

Vancouver

Bang U, Viby‐Mogensen J, Wirén JE, Skovgaard LT. The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. Acta Anaesthesiologica Scandinavica Supplementum. 1990 okt.;34(7):596-599. https://doi.org/10.1111/j.1399-6576.1990.tb03152.x

Author

Bang, U. ; Viby‐Mogensen, J. ; Wirén, J. E. ; Skovgaard, L. Theil. / The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. I: Acta Anaesthesiologica Scandinavica Supplementum. 1990 ; Bind 34, Nr. 7. s. 596-599.

Bibtex

@article{b5678ac5da064bd9a5c9e3fc5671e56f,
title = "The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients",
abstract = "Bambuterol (the bisdimethylcarbamate prodrug of terbutaline) is a new bronchodilator with a prolonged duration of action due to its inhibition of plasma cholinesterase during metabolism. The effect of bambuterol on suxamethonium‐induced neuromuscular blockade was studied in 10 patients undergoing elective laparotomy. Thirty mg of bambuterol was given 2 h before anaesthesia, which was performed with thiopentone, fentanyl, halothane and nitrous oxide in oxygen. Neuromuscular function was monitored using supramaximal train‐of‐four stimulation of the ulnar nerve and a force displacement transducer. Suxamethonium 1 mg ± kg‐1 was given i.v. for endotracheal intubation. Plasma cholinesterase activity was measured before and after intake of bambuterol and during anaesthesia. The results from the 10 patients were compared with those of 41 patients not given bambuterol but otherwise studied during the same conditions. Following bambuterol, all patients had a significant decrease of plasma cholinesterase activity (P< 0.001) and the suxamethonium‐induced blockade was 3–4 times prolonged compared to patients not given bambuterol (P<0.001). Five patients with very low plasma cholinesterase activity developed a long‐lasting phase II block.",
keywords = "Enzymes: plasma cholinesterase, interactions: bambuterol, monitoring: neuromuscuar function, neuromuscular relaxants: succinylcholine, pharmacology: bambuterol, plasma cholinesterase, succinyl‐choline",
author = "U. Bang and J. Viby‐Mogensen and Wir{\'e}n, {J. E.} and Skovgaard, {L. Theil}",
year = "1990",
month = oct,
doi = "10.1111/j.1399-6576.1990.tb03152.x",
language = "English",
volume = "34",
pages = "596--599",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients

AU - Bang, U.

AU - Viby‐Mogensen, J.

AU - Wirén, J. E.

AU - Skovgaard, L. Theil

PY - 1990/10

Y1 - 1990/10

N2 - Bambuterol (the bisdimethylcarbamate prodrug of terbutaline) is a new bronchodilator with a prolonged duration of action due to its inhibition of plasma cholinesterase during metabolism. The effect of bambuterol on suxamethonium‐induced neuromuscular blockade was studied in 10 patients undergoing elective laparotomy. Thirty mg of bambuterol was given 2 h before anaesthesia, which was performed with thiopentone, fentanyl, halothane and nitrous oxide in oxygen. Neuromuscular function was monitored using supramaximal train‐of‐four stimulation of the ulnar nerve and a force displacement transducer. Suxamethonium 1 mg ± kg‐1 was given i.v. for endotracheal intubation. Plasma cholinesterase activity was measured before and after intake of bambuterol and during anaesthesia. The results from the 10 patients were compared with those of 41 patients not given bambuterol but otherwise studied during the same conditions. Following bambuterol, all patients had a significant decrease of plasma cholinesterase activity (P< 0.001) and the suxamethonium‐induced blockade was 3–4 times prolonged compared to patients not given bambuterol (P<0.001). Five patients with very low plasma cholinesterase activity developed a long‐lasting phase II block.

AB - Bambuterol (the bisdimethylcarbamate prodrug of terbutaline) is a new bronchodilator with a prolonged duration of action due to its inhibition of plasma cholinesterase during metabolism. The effect of bambuterol on suxamethonium‐induced neuromuscular blockade was studied in 10 patients undergoing elective laparotomy. Thirty mg of bambuterol was given 2 h before anaesthesia, which was performed with thiopentone, fentanyl, halothane and nitrous oxide in oxygen. Neuromuscular function was monitored using supramaximal train‐of‐four stimulation of the ulnar nerve and a force displacement transducer. Suxamethonium 1 mg ± kg‐1 was given i.v. for endotracheal intubation. Plasma cholinesterase activity was measured before and after intake of bambuterol and during anaesthesia. The results from the 10 patients were compared with those of 41 patients not given bambuterol but otherwise studied during the same conditions. Following bambuterol, all patients had a significant decrease of plasma cholinesterase activity (P< 0.001) and the suxamethonium‐induced blockade was 3–4 times prolonged compared to patients not given bambuterol (P<0.001). Five patients with very low plasma cholinesterase activity developed a long‐lasting phase II block.

KW - Enzymes: plasma cholinesterase

KW - interactions: bambuterol

KW - monitoring: neuromuscuar function

KW - neuromuscular relaxants: succinylcholine

KW - pharmacology: bambuterol

KW - plasma cholinesterase

KW - succinyl‐choline

UR - http://www.scopus.com/inward/record.url?scp=0025144977&partnerID=8YFLogxK

U2 - 10.1111/j.1399-6576.1990.tb03152.x

DO - 10.1111/j.1399-6576.1990.tb03152.x

M3 - Journal article

C2 - 2244449

AN - SCOPUS:0025144977

VL - 34

SP - 596

EP - 599

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 7

ER -

ID: 259166101