The clinical impact of mRNA therapeutics in the treatment of cancers, infections, genetic disorders, and autoimmune diseases
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The clinical impact of mRNA therapeutics in the treatment of cancers, infections, genetic disorders, and autoimmune diseases. / Deyhimfar, Roham; Izady, Mehrnaz; Shoghi, Mohammadreza; Kazazi, Mohammad Hossein; Ghazvini, Zahra Fakhraei; Nazari, Hojjatollah; Fekrirad, Zahra; Arefian, Ehsan.
I: Heliyon, Bind 10, Nr. 5, e26971, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The clinical impact of mRNA therapeutics in the treatment of cancers, infections, genetic disorders, and autoimmune diseases
AU - Deyhimfar, Roham
AU - Izady, Mehrnaz
AU - Shoghi, Mohammadreza
AU - Kazazi, Mohammad Hossein
AU - Ghazvini, Zahra Fakhraei
AU - Nazari, Hojjatollah
AU - Fekrirad, Zahra
AU - Arefian, Ehsan
N1 - Publisher Copyright: © 2024
PY - 2024
Y1 - 2024
N2 - mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options. Furthermore, the development and deployment of mRNA vaccines have facilitated a prompt and flexible response to medical emergencies, exemplified by the COVID-19 outbreak. The establishment of stable and safe mRNA molecules carried by efficient delivery systems is now available through recent advances in molecular biology and nanotechnology. This review aims to elucidate the advancements in the clinical applications of mRNAs for addressing significant health-related challenges such as cancer, autoimmune diseases, genetic disorders, and infections and provide insights into the efficacy and safety of mRNA therapeutics in recent clinical trials.
AB - mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options. Furthermore, the development and deployment of mRNA vaccines have facilitated a prompt and flexible response to medical emergencies, exemplified by the COVID-19 outbreak. The establishment of stable and safe mRNA molecules carried by efficient delivery systems is now available through recent advances in molecular biology and nanotechnology. This review aims to elucidate the advancements in the clinical applications of mRNAs for addressing significant health-related challenges such as cancer, autoimmune diseases, genetic disorders, and infections and provide insights into the efficacy and safety of mRNA therapeutics in recent clinical trials.
KW - Autoimmune diseases
KW - Cancer
KW - Genetic disorders
KW - mRNA therapy
KW - Vaccine
U2 - 10.1016/j.heliyon.2024.e26971
DO - 10.1016/j.heliyon.2024.e26971
M3 - Review
C2 - 38486748
AN - SCOPUS:85187321243
VL - 10
JO - Heliyon
JF - Heliyon
SN - 2405-8440
IS - 5
M1 - e26971
ER -
ID: 385581637