The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.

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Standard

The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells. / Muñoz, A; Höppner, W; Sap, J; Brady, G; Nordström, K; Seitz, H J; Vennström, B.

I: Molecular Endocrinology, Bind 4, Nr. 2, 1990, s. 312-20.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Muñoz, A, Höppner, W, Sap, J, Brady, G, Nordström, K, Seitz, HJ & Vennström, B 1990, 'The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.', Molecular Endocrinology, bind 4, nr. 2, s. 312-20.

APA

Muñoz, A., Höppner, W., Sap, J., Brady, G., Nordström, K., Seitz, H. J., & Vennström, B. (1990). The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells. Molecular Endocrinology, 4(2), 312-20.

Vancouver

Muñoz A, Höppner W, Sap J, Brady G, Nordström K, Seitz HJ o.a. The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells. Molecular Endocrinology. 1990;4(2):312-20.

Author

Muñoz, A ; Höppner, W ; Sap, J ; Brady, G ; Nordström, K ; Seitz, H J ; Vennström, B. / The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells. I: Molecular Endocrinology. 1990 ; Bind 4, Nr. 2. s. 312-20.

Bibtex

@article{1b1ca38054ad11dd8d9f000ea68e967b,
title = "The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.",
abstract = "To determine the capacity of the chicken c-erbA (cTR-alpha) gene product in regulating expression of known thyroid hormone-responsive genes, both the cTR-alpha and the viral v-erbA genes were expressed in FAO cells, a rat hepatoma cell line defective for functional thyroid hormone receptors. Upon nuclear expression of the cTR-alpha protein the cells become responsive to thyroid hormone, as detected by expression of a number of genes (malic enzyme, phosphoenolpyruvate carboxykinase, and Na+/K(+)-ATPase) reported to be indirectly induced by the hormone in vivo. In addition, our data show that the c-erbA product directly activates the Moloney murine leukemia virus promoter in a ligand-dependent manner. The data show that the chicken c-erbA-alpha protein can modulate the expression of rat genes under either direct or indirect control by thyroid hormone.",
author = "A Mu{\~n}oz and W H{\"o}ppner and J Sap and G Brady and K Nordstr{\"o}m and Seitz, {H J} and B Vennstr{\"o}m",
note = "Keywords: Animals; Base Sequence; Chickens; Cycloheximide; Gene Expression; Genes; Genomic Library; Liver Neoplasms, Experimental; Malate Dehydrogenase; Molecular Sequence Data; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions (Genetics); Proto-Oncogene Proteins; Rats; Receptors, Thyroid Hormone; Retroviridae Infections; Sodium-Potassium-Exchanging ATPase; Thyroid Hormones; Transcription, Genetic; Triiodothyronine",
year = "1990",
language = "English",
volume = "4",
pages = "312--20",
journal = "Molecular Endocrinology",
issn = "0888-8809",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.

AU - Muñoz, A

AU - Höppner, W

AU - Sap, J

AU - Brady, G

AU - Nordström, K

AU - Seitz, H J

AU - Vennström, B

N1 - Keywords: Animals; Base Sequence; Chickens; Cycloheximide; Gene Expression; Genes; Genomic Library; Liver Neoplasms, Experimental; Malate Dehydrogenase; Molecular Sequence Data; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions (Genetics); Proto-Oncogene Proteins; Rats; Receptors, Thyroid Hormone; Retroviridae Infections; Sodium-Potassium-Exchanging ATPase; Thyroid Hormones; Transcription, Genetic; Triiodothyronine

PY - 1990

Y1 - 1990

N2 - To determine the capacity of the chicken c-erbA (cTR-alpha) gene product in regulating expression of known thyroid hormone-responsive genes, both the cTR-alpha and the viral v-erbA genes were expressed in FAO cells, a rat hepatoma cell line defective for functional thyroid hormone receptors. Upon nuclear expression of the cTR-alpha protein the cells become responsive to thyroid hormone, as detected by expression of a number of genes (malic enzyme, phosphoenolpyruvate carboxykinase, and Na+/K(+)-ATPase) reported to be indirectly induced by the hormone in vivo. In addition, our data show that the c-erbA product directly activates the Moloney murine leukemia virus promoter in a ligand-dependent manner. The data show that the chicken c-erbA-alpha protein can modulate the expression of rat genes under either direct or indirect control by thyroid hormone.

AB - To determine the capacity of the chicken c-erbA (cTR-alpha) gene product in regulating expression of known thyroid hormone-responsive genes, both the cTR-alpha and the viral v-erbA genes were expressed in FAO cells, a rat hepatoma cell line defective for functional thyroid hormone receptors. Upon nuclear expression of the cTR-alpha protein the cells become responsive to thyroid hormone, as detected by expression of a number of genes (malic enzyme, phosphoenolpyruvate carboxykinase, and Na+/K(+)-ATPase) reported to be indirectly induced by the hormone in vivo. In addition, our data show that the c-erbA product directly activates the Moloney murine leukemia virus promoter in a ligand-dependent manner. The data show that the chicken c-erbA-alpha protein can modulate the expression of rat genes under either direct or indirect control by thyroid hormone.

M3 - Journal article

C2 - 2158623

VL - 4

SP - 312

EP - 320

JO - Molecular Endocrinology

JF - Molecular Endocrinology

SN - 0888-8809

IS - 2

ER -

ID: 5070180