Testicular function in young men in long-term remission after treatment for the early stages of Hodgkin's disease
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Testicular function in young men in long-term remission after treatment for the early stages of Hodgkin's disease. / Specht, L.; Geisler, C.; Hansen, M.M.; Skakkebaek, N.E.
I: Scand.J Haematol., Bind 33, Nr. 4, 1984, s. 356-362.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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TY - JOUR
T1 - Testicular function in young men in long-term remission after treatment for the early stages of Hodgkin's disease
AU - Specht, L.
AU - Geisler, C.
AU - Hansen, M.M.
AU - Skakkebaek, N.E.
N1 - UI - 85065635LA - engPT - Journal ArticleDA - 19850118IS - 0036-553XSB - IMCY - DENMARK
PY - 1984
Y1 - 1984
N2 - 16 young men in long-term remission after standard treatment for the early stages of Hodgkin's disease were examined for testicular function 48 to 125 months after termination of therapy. The patients had received mantle field irradiation, plus either irradiation of infradiaphragmatic lymph nodes (7 patients) or 6 cycles of MOPP (9 patients). 5 patients had almost normal semen quality judged by seminal fluid analysis. 11 patients had reduced semen quality (8 severely reduced) and often elevated FSH values. Semen samples of poor quality were significantly more common in patients treated with MOPP (7/9) than in those treated with infradiaphragmatic irradiation (1/7). One patient showed signs of regeneration of spermatogenesis. None had experienced reduction in libido and sexual performance after therapy; correspondingly, none had below normal testosterone values or elevated LH values. Patients should be informed about the risk of infertility before treatment. If in a given case several treatment options with equal prospective antineoplastic effect are weighed against one another, the patient's possible desire to retain fertility should favour the use of radiotherapy as opposed to chemotherapy, especially including alkylating agents Udgivelsesdato: 1984/10
AB - 16 young men in long-term remission after standard treatment for the early stages of Hodgkin's disease were examined for testicular function 48 to 125 months after termination of therapy. The patients had received mantle field irradiation, plus either irradiation of infradiaphragmatic lymph nodes (7 patients) or 6 cycles of MOPP (9 patients). 5 patients had almost normal semen quality judged by seminal fluid analysis. 11 patients had reduced semen quality (8 severely reduced) and often elevated FSH values. Semen samples of poor quality were significantly more common in patients treated with MOPP (7/9) than in those treated with infradiaphragmatic irradiation (1/7). One patient showed signs of regeneration of spermatogenesis. None had experienced reduction in libido and sexual performance after therapy; correspondingly, none had below normal testosterone values or elevated LH values. Patients should be informed about the risk of infertility before treatment. If in a given case several treatment options with equal prospective antineoplastic effect are weighed against one another, the patient's possible desire to retain fertility should favour the use of radiotherapy as opposed to chemotherapy, especially including alkylating agents Udgivelsesdato: 1984/10
M3 - Tidsskriftartikel
VL - 33
SP - 356
EP - 362
JO - Scandinavian Journal of Haematology
JF - Scandinavian Journal of Haematology
SN - 0036-553X
IS - 4
ER -
ID: 19398964