Systematic Strategy for Developing Glycosyltransferase Inhibitors

Systematic Strategy for Developing Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors

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Standard

Systematic Strategy for Developing Glycosyltransferase Inhibitors : Diversity-Oriented Synthesis of FUT8 Inhibitors. / Manabe, Yoshiyuki; Hizume, Koki; Takakura, Yohei; Takamatsu, Shinji; Miyoshi, Eiji; Kamad, Yoshihiro; Hurtado-Guerrer, Ramón; Fukase, Koichi.

I: Synlett, Bind 35, Nr. 11, 2024, s. 1273-1278.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Manabe, Y, Hizume, K, Takakura, Y, Takamatsu, S, Miyoshi, E, Kamad, Y, Hurtado-Guerrer, R & Fukase, K 2024, 'Systematic Strategy for Developing Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors', Synlett, bind 35, nr. 11, s. 1273-1278. https://doi.org/10.1055/a-2221-9096

APA

Manabe, Y., Hizume, K., Takakura, Y., Takamatsu, S., Miyoshi, E., Kamad, Y., Hurtado-Guerrer, R., & Fukase, K. (2024). Systematic Strategy for Developing Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors. Synlett, 35(11), 1273-1278. https://doi.org/10.1055/a-2221-9096

Vancouver

Manabe Y, Hizume K, Takakura Y, Takamatsu S, Miyoshi E, Kamad Y o.a. Systematic Strategy for Developing Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors. Synlett. 2024;35(11):1273-1278. https://doi.org/10.1055/a-2221-9096

Author

Manabe, Yoshiyuki ; Hizume, Koki ; Takakura, Yohei ; Takamatsu, Shinji ; Miyoshi, Eiji ; Kamad, Yoshihiro ; Hurtado-Guerrer, Ramón ; Fukase, Koichi. / Systematic Strategy for Developing Glycosyltransferase Inhibitors : Diversity-Oriented Synthesis of FUT8 Inhibitors. I: Synlett. 2024 ; Bind 35, Nr. 11. s. 1273-1278.

Bibtex

@article{c468a0aa1fd742f7bd5796052f8bb2bc,

title = "Systematic Strategy for Developing Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors",

abstract = "Glycans control various biological processes depending on their structures. Particularly, core fucose, formed by a1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated the development of FUT8 inhibitors with structural elements encompassing both the glycosyl donor (GDP-fucose) and acceptor (N-glycan) of FUT8. To efficiently optimize the structure of FUT8 inhibitors, we employed a strategy involving fragmentation of the target structure, followed by the structure optimization using diversity-oriented synthesis approaches. This study proposes an efficient strategy to accelerate the structural optimization of middle molecules.",

keywords = "compound library, diversity-oriented synthesis, glycosyltransferase, inhibitor, middle molecule",

author = "Yoshiyuki Manabe and Koki Hizume and Yohei Takakura and Shinji Takamatsu and Eiji Miyoshi and Yoshihiro Kamad and Ram{\'o}n Hurtado-Guerrer and Koichi Fukase",

year = "2024",

doi = "10.1055/a-2221-9096",

language = "English",

volume = "35",

pages = "1273--1278",

journal = "SYNLETT: Accounts and Rapid Communications in Chemical Synthesis",

issn = "0936-5214",

publisher = "Thieme",

number = "11",

}

RIS

TY - JOUR

T1 - Systematic Strategy for Developing Glycosyltransferase Inhibitors

T2 - Diversity-Oriented Synthesis of FUT8 Inhibitors

AU - Manabe, Yoshiyuki

AU - Hizume, Koki

AU - Takakura, Yohei

AU - Takamatsu, Shinji

AU - Miyoshi, Eiji

AU - Kamad, Yoshihiro

AU - Hurtado-Guerrer, Ramón

AU - Fukase, Koichi

PY - 2024

Y1 - 2024

N2 - Glycans control various biological processes depending on their structures. Particularly, core fucose, formed by a1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated the development of FUT8 inhibitors with structural elements encompassing both the glycosyl donor (GDP-fucose) and acceptor (N-glycan) of FUT8. To efficiently optimize the structure of FUT8 inhibitors, we employed a strategy involving fragmentation of the target structure, followed by the structure optimization using diversity-oriented synthesis approaches. This study proposes an efficient strategy to accelerate the structural optimization of middle molecules.

AB - Glycans control various biological processes depending on their structures. Particularly, core fucose, formed by a1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated the development of FUT8 inhibitors with structural elements encompassing both the glycosyl donor (GDP-fucose) and acceptor (N-glycan) of FUT8. To efficiently optimize the structure of FUT8 inhibitors, we employed a strategy involving fragmentation of the target structure, followed by the structure optimization using diversity-oriented synthesis approaches. This study proposes an efficient strategy to accelerate the structural optimization of middle molecules.

KW - compound library

KW - diversity-oriented synthesis

KW - glycosyltransferase

KW - inhibitor

KW - middle molecule

U2 - 10.1055/a-2221-9096

DO - 10.1055/a-2221-9096

M3 - Journal article

AN - SCOPUS:85179737044

VL - 35

SP - 1273

EP - 1278

JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

SN - 0936-5214

IS - 11

ER -

ID: 389365237

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