suPAR: the molecular crystal ball

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

suPAR: the molecular crystal ball. / Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper.

I: Disease Markers, Bind 27, Nr. 3, 2009, s. 157-72.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Thunø, M, Macho, B & Eugen-Olsen, J 2009, 'suPAR: the molecular crystal ball', Disease Markers, bind 27, nr. 3, s. 157-72. https://doi.org/10.3233/DMA-2009-0657

APA

Thunø, M., Macho, B., & Eugen-Olsen, J. (2009). suPAR: the molecular crystal ball. Disease Markers, 27(3), 157-72. https://doi.org/10.3233/DMA-2009-0657

Vancouver

Thunø M, Macho B, Eugen-Olsen J. suPAR: the molecular crystal ball. Disease Markers. 2009;27(3):157-72. https://doi.org/10.3233/DMA-2009-0657

Author

Thunø, Maria ; Macho, Betina ; Eugen-Olsen, Jesper. / suPAR: the molecular crystal ball. I: Disease Markers. 2009 ; Bind 27, Nr. 3. s. 157-72.

Bibtex

@article{11b01de0aac811df928f000ea68e967b,
title = "suPAR: the molecular crystal ball",
abstract = "soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas the cleaved suPAR(II-III) act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions.",
author = "Maria Thun{\o} and Betina Macho and Jesper Eugen-Olsen",
note = "Keywords: Communicable Diseases; Humans; Inflammation; Neoplasms; Receptors, Urokinase Plasminogen Activator",
year = "2009",
doi = "10.3233/DMA-2009-0657",
language = "English",
volume = "27",
pages = "157--72",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "Hindawi Publishing Corporation",
number = "3",

}

RIS

TY - JOUR

T1 - suPAR: the molecular crystal ball

AU - Thunø, Maria

AU - Macho, Betina

AU - Eugen-Olsen, Jesper

N1 - Keywords: Communicable Diseases; Humans; Inflammation; Neoplasms; Receptors, Urokinase Plasminogen Activator

PY - 2009

Y1 - 2009

N2 - soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas the cleaved suPAR(II-III) act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions.

AB - soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas the cleaved suPAR(II-III) act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions.

U2 - 10.3233/DMA-2009-0657

DO - 10.3233/DMA-2009-0657

M3 - Journal article

C2 - 19893210

VL - 27

SP - 157

EP - 172

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

IS - 3

ER -

ID: 21458663