Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36

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Standard

Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. / Iepsen, Eva W; Lundgren, Julie; Holst, Jens J; Madsbad, Sten; Torekov, Signe S.

I: European Journal of Endocrinology, Bind 174, Nr. 6, 06.2016, s. 775-784.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Iepsen, EW, Lundgren, J, Holst, JJ, Madsbad, S & Torekov, SS 2016, 'Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36', European Journal of Endocrinology, bind 174, nr. 6, s. 775-784. https://doi.org/10.1530/EJE-15-1116

APA

Iepsen, E. W., Lundgren, J., Holst, J. J., Madsbad, S., & Torekov, S. S. (2016). Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. European Journal of Endocrinology, 174(6), 775-784. https://doi.org/10.1530/EJE-15-1116

Vancouver

Iepsen EW, Lundgren J, Holst JJ, Madsbad S, Torekov SS. Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. European Journal of Endocrinology. 2016 jun;174(6):775-784. https://doi.org/10.1530/EJE-15-1116

Author

Iepsen, Eva W ; Lundgren, Julie ; Holst, Jens J ; Madsbad, Sten ; Torekov, Signe S. / Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. I: European Journal of Endocrinology. 2016 ; Bind 174, Nr. 6. s. 775-784.

Bibtex

@article{c4090b39ed30467cbfc9246e0b7a65b7,
title = "Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36",
abstract = "OBJECTIVE: The hormones glucagon-like peptide 1 (GLP-1), peptide YY3-36 (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.DESIGN: The study was designed as a longitudinal prospective intervention study with data obtained at baseline, after 8 weeks of weight loss and 1 year after weight loss.METHODS: Twenty healthy obese individuals obtained a 13{\%} weight loss by adhering to an 8-week very low-calorie diet (800kcal/day). After weight loss, participants entered a 52-week weight maintenance protocol. Plasma levels of GLP-1, PYY3-36, ghrelin, GIP and glucagon during a 600-kcal meal were measured before weight loss, after weight loss and after 1 year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).RESULTS: Weight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 44{\%} after weight loss (P<0.04) and increased to 72{\%} at week 52 (P=0.0001). iAUC for PYY3-36 increased by 74{\%} after weight loss (P<0.0001) and by 36{\%} at week 52 (P=0.02). tAUC for ghrelin increased by 23{\%} after weight loss (P<0.0001), but at week 52, the increase was reduced to 16{\%} compared with before weight loss (P=0.005). iAUC for GIP increased by 36{\%} after weight loss (P=0.001), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.CONCLUSIONS: Meal responses of GLP-1 and PYY3-36 remained increased 1 year after weight maintenance, whereas ghrelin and GIP reverted toward before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite-stimulating mechanisms appear to contribute to successful long-term weight loss maintenance.",
author = "Iepsen, {Eva W} and Julie Lundgren and Holst, {Jens J} and Sten Madsbad and Torekov, {Signe S}",
note = "{\circledC} 2016 European Society of Endocrinology.",
year = "2016",
month = "6",
doi = "10.1530/EJE-15-1116",
language = "English",
volume = "174",
pages = "775--784",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36

AU - Iepsen, Eva W

AU - Lundgren, Julie

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Torekov, Signe S

N1 - © 2016 European Society of Endocrinology.

PY - 2016/6

Y1 - 2016/6

N2 - OBJECTIVE: The hormones glucagon-like peptide 1 (GLP-1), peptide YY3-36 (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.DESIGN: The study was designed as a longitudinal prospective intervention study with data obtained at baseline, after 8 weeks of weight loss and 1 year after weight loss.METHODS: Twenty healthy obese individuals obtained a 13% weight loss by adhering to an 8-week very low-calorie diet (800kcal/day). After weight loss, participants entered a 52-week weight maintenance protocol. Plasma levels of GLP-1, PYY3-36, ghrelin, GIP and glucagon during a 600-kcal meal were measured before weight loss, after weight loss and after 1 year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).RESULTS: Weight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 44% after weight loss (P<0.04) and increased to 72% at week 52 (P=0.0001). iAUC for PYY3-36 increased by 74% after weight loss (P<0.0001) and by 36% at week 52 (P=0.02). tAUC for ghrelin increased by 23% after weight loss (P<0.0001), but at week 52, the increase was reduced to 16% compared with before weight loss (P=0.005). iAUC for GIP increased by 36% after weight loss (P=0.001), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.CONCLUSIONS: Meal responses of GLP-1 and PYY3-36 remained increased 1 year after weight maintenance, whereas ghrelin and GIP reverted toward before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite-stimulating mechanisms appear to contribute to successful long-term weight loss maintenance.

AB - OBJECTIVE: The hormones glucagon-like peptide 1 (GLP-1), peptide YY3-36 (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.DESIGN: The study was designed as a longitudinal prospective intervention study with data obtained at baseline, after 8 weeks of weight loss and 1 year after weight loss.METHODS: Twenty healthy obese individuals obtained a 13% weight loss by adhering to an 8-week very low-calorie diet (800kcal/day). After weight loss, participants entered a 52-week weight maintenance protocol. Plasma levels of GLP-1, PYY3-36, ghrelin, GIP and glucagon during a 600-kcal meal were measured before weight loss, after weight loss and after 1 year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).RESULTS: Weight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 44% after weight loss (P<0.04) and increased to 72% at week 52 (P=0.0001). iAUC for PYY3-36 increased by 74% after weight loss (P<0.0001) and by 36% at week 52 (P=0.02). tAUC for ghrelin increased by 23% after weight loss (P<0.0001), but at week 52, the increase was reduced to 16% compared with before weight loss (P=0.005). iAUC for GIP increased by 36% after weight loss (P=0.001), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.CONCLUSIONS: Meal responses of GLP-1 and PYY3-36 remained increased 1 year after weight maintenance, whereas ghrelin and GIP reverted toward before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite-stimulating mechanisms appear to contribute to successful long-term weight loss maintenance.

U2 - 10.1530/EJE-15-1116

DO - 10.1530/EJE-15-1116

M3 - Journal article

C2 - 26976129

VL - 174

SP - 775

EP - 784

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 6

ER -

ID: 166945898