TY - JOUR

T1 - Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring

AU - Danielsen, Inge

AU - Granström, Charlotta

AU - Rytter, Dorte

AU - Halldorsson, Thorhallur I

AU - Bech, Bodil Hammer

AU - Henriksen, Tine Brink

AU - Stehouwer, Coen D A

AU - Schalkwijk, Casper G

AU - Vaag, Allan A

AU - Olsen, Sjurdur F

N1 - Copyright © 2013 The Obesity Society.

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.

AB - OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.

KW - Adult

KW - Biological Markers

KW - Blood Glucose

KW - Blood Pressure

KW - Body Mass Index

KW - C-Reactive Protein

KW - Cholesterol

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Inflammation

KW - Insulin

KW - Insulin Resistance

KW - Interleukin-1beta

KW - Interleukin-6

KW - Leptin

KW - Linear Models

KW - Longitudinal Studies

KW - Male

KW - Metabolic Syndrome X

KW - Multivariate Analysis

KW - Pregnancy

KW - Pregnancy Trimester, Third

KW - Triglycerides

KW - Tumor Necrosis Factor-alpha

KW - Waist Circumference

KW - Young Adult

U2 - 10.1002/oby.20650

DO - 10.1002/oby.20650

M3 - Journal article

C2 - 24167021

VL - 22

SP - 1351

EP - 1358

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -