Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

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Standard

Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. / Jensen, D H; Aaboe, K; Henriksen, J E; Vølund, Anders; Holst, Jens Juul; Madsbad, S; Krarup, T.

I: Diabetologia, Bind 55, Nr. 5, 2012, s. 1406-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, DH, Aaboe, K, Henriksen, JE, Vølund, A, Holst, JJ, Madsbad, S & Krarup, T 2012, 'Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes', Diabetologia, bind 55, nr. 5, s. 1406-16. https://doi.org/10.1007/s00125-012-2459-7

APA

Jensen, D. H., Aaboe, K., Henriksen, J. E., Vølund, A., Holst, J. J., Madsbad, S., & Krarup, T. (2012). Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. Diabetologia, 55(5), 1406-16. https://doi.org/10.1007/s00125-012-2459-7

Vancouver

Jensen DH, Aaboe K, Henriksen JE, Vølund A, Holst JJ, Madsbad S o.a. Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. Diabetologia. 2012;55(5):1406-16. https://doi.org/10.1007/s00125-012-2459-7

Author

Jensen, D H ; Aaboe, K ; Henriksen, J E ; Vølund, Anders ; Holst, Jens Juul ; Madsbad, S ; Krarup, T. / Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. I: Diabetologia. 2012 ; Bind 55, Nr. 5. s. 1406-16.

Bibtex

@article{caa5693fb1de4593a19a990cef624a7f,
title = "Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes",
abstract = "AIMS/HYPOTHESIS: The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect. METHODS: Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g OGTT, an isoglycaemic i.v. glucose test and a mixed meal to evaluate the incretin effect before and after treatment with dexamethasone to increase insulin resistance. Beta cell glucose sensitivity, beta cell index and fasting proinsulin were measured as indices of beta cell function. RESULTS: After dexamethasone, ten individuals had increased insulin resistance but normal glucose tolerance (NGT), while 11 individuals with an equal increase in insulin resistance developed IGT. In the NGT and IGT groups, the incretin effects were 71¿±¿3.2% and 67¿±¿4.6% (p¿=¿0.4) before treatment, but decreased significantly in both groups to 58¿±¿5.2% and 32¿±¿8.8% (p¿",
author = "Jensen, {D H} and K Aaboe and Henriksen, {J E} and Anders V{\o}lund and Holst, {Jens Juul} and S Madsbad and T Krarup",
year = "2012",
doi = "10.1007/s00125-012-2459-7",
language = "English",
volume = "55",
pages = "1406--16",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

AU - Jensen, D H

AU - Aaboe, K

AU - Henriksen, J E

AU - Vølund, Anders

AU - Holst, Jens Juul

AU - Madsbad, S

AU - Krarup, T

PY - 2012

Y1 - 2012

N2 - AIMS/HYPOTHESIS: The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect. METHODS: Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g OGTT, an isoglycaemic i.v. glucose test and a mixed meal to evaluate the incretin effect before and after treatment with dexamethasone to increase insulin resistance. Beta cell glucose sensitivity, beta cell index and fasting proinsulin were measured as indices of beta cell function. RESULTS: After dexamethasone, ten individuals had increased insulin resistance but normal glucose tolerance (NGT), while 11 individuals with an equal increase in insulin resistance developed IGT. In the NGT and IGT groups, the incretin effects were 71¿±¿3.2% and 67¿±¿4.6% (p¿=¿0.4) before treatment, but decreased significantly in both groups to 58¿±¿5.2% and 32¿±¿8.8% (p¿

AB - AIMS/HYPOTHESIS: The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect. METHODS: Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g OGTT, an isoglycaemic i.v. glucose test and a mixed meal to evaluate the incretin effect before and after treatment with dexamethasone to increase insulin resistance. Beta cell glucose sensitivity, beta cell index and fasting proinsulin were measured as indices of beta cell function. RESULTS: After dexamethasone, ten individuals had increased insulin resistance but normal glucose tolerance (NGT), while 11 individuals with an equal increase in insulin resistance developed IGT. In the NGT and IGT groups, the incretin effects were 71¿±¿3.2% and 67¿±¿4.6% (p¿=¿0.4) before treatment, but decreased significantly in both groups to 58¿±¿5.2% and 32¿±¿8.8% (p¿

U2 - 10.1007/s00125-012-2459-7

DO - 10.1007/s00125-012-2459-7

M3 - Journal article

C2 - 22286551

VL - 55

SP - 1406

EP - 1416

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 5

ER -

ID: 38474978