TY - JOUR

T1 - ß2 -adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66¿750 individuals

AU - Thomsen, M

AU - Dahl, Morten

AU - Tybjaerg-Hansen, A

AU - Nordestgaard, B G

N1 - © 2011 The Association for the Publication of the Journal of Internal Medicine.

PY - 2012

Y1 - 2012

N2 - The ß(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of cardiovascular disease (CVD).

AB - The ß(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of cardiovascular disease (CVD).

KW - Aged

KW - Blood Pressure

KW - Cross-Sectional Studies

KW - Denmark

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - Myocardial Ischemia

KW - Myocytes, Smooth Muscle

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Questionnaires

KW - Receptors, Adrenergic, beta-2

KW - Sex Factors

U2 - 10.1111/j.1365-2796.2011.02447.x

DO - 10.1111/j.1365-2796.2011.02447.x

M3 - Journal article

C2 - 21883537

VL - 271

SP - 305

EP - 314

JO - Acta Medica Scandinavica

JF - Acta Medica Scandinavica

SN - 0955-7873

IS - 3

ER -