Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event. / Pareek, Manan; Bhatt, Deepak L.; Vaduganathan, Muthiah; Biering-Sørensen, Tor; Qamar, Arman; Diederichsen, Axel C.P.; Møller, Jacob Eifer; Hindersson, Peter; Leósdóttir, Margrét; Magnusson, Martin; Nilsson, Peter M.; Olsen, Michael H.

I: European Journal of Preventive Cardiology, Bind 24, Nr. 15, 2017, s. 1648-1659.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Pareek, M, Bhatt, DL, Vaduganathan, M, Biering-Sørensen, T, Qamar, A, Diederichsen, ACP, Møller, JE, Hindersson, P, Leósdóttir, M, Magnusson, M, Nilsson, PM & Olsen, MH 2017, 'Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event', European Journal of Preventive Cardiology, bind 24, nr. 15, s. 1648-1659. https://doi.org/10.1177/2047487317717065

APA

Pareek, M., Bhatt, D. L., Vaduganathan, M., Biering-Sørensen, T., Qamar, A., Diederichsen, A. C. P., Møller, J. E., Hindersson, P., Leósdóttir, M., Magnusson, M., Nilsson, P. M., & Olsen, M. H. (2017). Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event. European Journal of Preventive Cardiology, 24(15), 1648-1659. https://doi.org/10.1177/2047487317717065

Vancouver

Pareek M, Bhatt DL, Vaduganathan M, Biering-Sørensen T, Qamar A, Diederichsen ACP o.a. Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event. European Journal of Preventive Cardiology. 2017;24(15):1648-1659. https://doi.org/10.1177/2047487317717065

Author

Pareek, Manan ; Bhatt, Deepak L. ; Vaduganathan, Muthiah ; Biering-Sørensen, Tor ; Qamar, Arman ; Diederichsen, Axel C.P. ; Møller, Jacob Eifer ; Hindersson, Peter ; Leósdóttir, Margrét ; Magnusson, Martin ; Nilsson, Peter M. ; Olsen, Michael H. / Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event. I: European Journal of Preventive Cardiology. 2017 ; Bind 24, Nr. 15. s. 1648-1659.

Bibtex

@article{0077f8cbcc2f46e695e3fd4fcb454de6,
title = "Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event",
abstract = "Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures. Methods and results Prospective population-based cohort study of 1324 subjects without a previous cardiovascular event, who underwent baseline echocardiography and biomarker assessment between 2002 and 2006. The clinical endpoint was the composite of myocardial infarction, invasively treated stable/unstable ischemic heart disease, heart failure, stroke, or all-cause mortality. Predictive capabilities were evaluated using Cox proportional-hazards regression, Harrell's concordance index (C-index), and net reclassification improvement. Median age was 66 (interquartile range: 60-70) years, and 413 (31%) were female. During median 8.6 (interquartile range: 8.1-9.2) follow-up years, 368 (28%) composite events occurred. NT-proBNP, hs-TnT, GDF-15, and IL-6 were significantly associated with outcome, independently of traditional risk factors, medications, and echocardiography (p < 0.05 for all). Separate addition of NT-proBNP and GDF-15 to traditional risk factors, medications, and echocardiographic measurements provided significant improvements in discriminative ability (NT-proBNP: C-index 0.714 vs. 0.703, p = 0.03; GDF-15: C-index 0.721 vs. 0.703, p = 0.02). Both biomarkers remained significant predictors of outcome upon inclusion in the same model (p < 0.05 for both). Conclusions NT-proBNP and GDF-15 each enhance prognostication beyond traditional risk factors, glucose levels, renal function, and echocardiography in individuals without known cardiovascular disease.",
keywords = "Biomarkers, discrimination, echocardiography, prognosis, reclassification",
author = "Manan Pareek and Bhatt, {Deepak L.} and Muthiah Vaduganathan and Tor Biering-S{\o}rensen and Arman Qamar and Diederichsen, {Axel C.P.} and M{\o}ller, {Jacob Eifer} and Peter Hindersson and Margr{\'e}t Le{\'o}sd{\'o}ttir and Martin Magnusson and Nilsson, {Peter M.} and Olsen, {Michael H.}",
note = "Publisher Copyright: {\textcopyright} European Society of Cardiology.",
year = "2017",
doi = "10.1177/2047487317717065",
language = "English",
volume = "24",
pages = "1648--1659",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications",
number = "15",

}

RIS

TY - JOUR

T1 - Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event

AU - Pareek, Manan

AU - Bhatt, Deepak L.

AU - Vaduganathan, Muthiah

AU - Biering-Sørensen, Tor

AU - Qamar, Arman

AU - Diederichsen, Axel C.P.

AU - Møller, Jacob Eifer

AU - Hindersson, Peter

AU - Leósdóttir, Margrét

AU - Magnusson, Martin

AU - Nilsson, Peter M.

AU - Olsen, Michael H.

N1 - Publisher Copyright: © European Society of Cardiology.

PY - 2017

Y1 - 2017

N2 - Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures. Methods and results Prospective population-based cohort study of 1324 subjects without a previous cardiovascular event, who underwent baseline echocardiography and biomarker assessment between 2002 and 2006. The clinical endpoint was the composite of myocardial infarction, invasively treated stable/unstable ischemic heart disease, heart failure, stroke, or all-cause mortality. Predictive capabilities were evaluated using Cox proportional-hazards regression, Harrell's concordance index (C-index), and net reclassification improvement. Median age was 66 (interquartile range: 60-70) years, and 413 (31%) were female. During median 8.6 (interquartile range: 8.1-9.2) follow-up years, 368 (28%) composite events occurred. NT-proBNP, hs-TnT, GDF-15, and IL-6 were significantly associated with outcome, independently of traditional risk factors, medications, and echocardiography (p < 0.05 for all). Separate addition of NT-proBNP and GDF-15 to traditional risk factors, medications, and echocardiographic measurements provided significant improvements in discriminative ability (NT-proBNP: C-index 0.714 vs. 0.703, p = 0.03; GDF-15: C-index 0.721 vs. 0.703, p = 0.02). Both biomarkers remained significant predictors of outcome upon inclusion in the same model (p < 0.05 for both). Conclusions NT-proBNP and GDF-15 each enhance prognostication beyond traditional risk factors, glucose levels, renal function, and echocardiography in individuals without known cardiovascular disease.

AB - Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures. Methods and results Prospective population-based cohort study of 1324 subjects without a previous cardiovascular event, who underwent baseline echocardiography and biomarker assessment between 2002 and 2006. The clinical endpoint was the composite of myocardial infarction, invasively treated stable/unstable ischemic heart disease, heart failure, stroke, or all-cause mortality. Predictive capabilities were evaluated using Cox proportional-hazards regression, Harrell's concordance index (C-index), and net reclassification improvement. Median age was 66 (interquartile range: 60-70) years, and 413 (31%) were female. During median 8.6 (interquartile range: 8.1-9.2) follow-up years, 368 (28%) composite events occurred. NT-proBNP, hs-TnT, GDF-15, and IL-6 were significantly associated with outcome, independently of traditional risk factors, medications, and echocardiography (p < 0.05 for all). Separate addition of NT-proBNP and GDF-15 to traditional risk factors, medications, and echocardiographic measurements provided significant improvements in discriminative ability (NT-proBNP: C-index 0.714 vs. 0.703, p = 0.03; GDF-15: C-index 0.721 vs. 0.703, p = 0.02). Both biomarkers remained significant predictors of outcome upon inclusion in the same model (p < 0.05 for both). Conclusions NT-proBNP and GDF-15 each enhance prognostication beyond traditional risk factors, glucose levels, renal function, and echocardiography in individuals without known cardiovascular disease.

KW - Biomarkers

KW - discrimination

KW - echocardiography

KW - prognosis

KW - reclassification

UR - http://www.scopus.com/inward/record.url?scp=85030683156&partnerID=8YFLogxK

U2 - 10.1177/2047487317717065

DO - 10.1177/2047487317717065

M3 - Journal article

C2 - 28644092

AN - SCOPUS:85030683156

VL - 24

SP - 1648

EP - 1659

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 15

ER -

ID: 322954766