Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes. / Kozawa, Junji; Okita, Kohei; Imagawa, Akihisa; Iwahashi, Hiromi; Holst, Jens Juul; Yamagata, Kazuya; Shimomura, Iichiro.
I: Biochemical and Biophysical Research Communications, Bind 393, Nr. 3, 12.03.2010, s. 410-3.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
AU - Kozawa, Junji
AU - Okita, Kohei
AU - Imagawa, Akihisa
AU - Iwahashi, Hiromi
AU - Holst, Jens Juul
AU - Yamagata, Kazuya
AU - Shimomura, Iichiro
N1 - 2010 Elsevier Inc. All rights reserved.
PY - 2010/3/12
Y1 - 2010/3/12
N2 - Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI > or = 25) and 4 patients were non-obese (BMI <25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.
AB - Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI > or = 25) and 4 patients were non-obese (BMI <25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.
KW - Body Mass Index
KW - C-Peptide
KW - Diabetes Mellitus, Type 2
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Incretins
KW - Insulin
KW - Middle Aged
KW - Obesity
U2 - 10.1016/j.bbrc.2010.01.134
DO - 10.1016/j.bbrc.2010.01.134
M3 - Journal article
C2 - 20138827
VL - 393
SP - 410
EP - 413
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -
ID: 33940196