Seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men
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Seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men. / Biggar, R. J.; Andersen, H. K.; Ebbesen, P.; Melbye, M.; Goedert, J. J.; Mann, D. L.; Strong, D. M.
I: BMJ Innovations, Bind 286, Nr. 6383, 1983, s. 2010-2012.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men
AU - Biggar, R. J.
AU - Andersen, H. K.
AU - Ebbesen, P.
AU - Melbye, M.
AU - Goedert, J. J.
AU - Mann, D. L.
AU - Strong, D. M.
PY - 1983
Y1 - 1983
N2 - Seminal fluid samples from 84 Danish homosexual men were successfully cultured to determine the prevalence of cytomegalovirus excretion. Ten (15%) out of 66 men positive for the antibody were found to be excreting the virus. Although the proportion excreting was inversely related to age (p <0.01), three men aged over 30 and with many years of homosexual experience excreted the virus. In addition, a 50 year old man with Kaposi's sarcoma excreted the virus. A further study of the ratio of T cell helpers to suppressors in the men aged over 30 and a series of age matched non-excreting homosexual control or heterosexual men showed that those excreting cytomegalovirus in their seminal fluid had statistically lower ratios (all <0.77) than the controls (p <0.05). Excretion of cytomegalovirus may be related to re-emergence of latent infection in immunosuppressed homosexual men.
AB - Seminal fluid samples from 84 Danish homosexual men were successfully cultured to determine the prevalence of cytomegalovirus excretion. Ten (15%) out of 66 men positive for the antibody were found to be excreting the virus. Although the proportion excreting was inversely related to age (p <0.01), three men aged over 30 and with many years of homosexual experience excreted the virus. In addition, a 50 year old man with Kaposi's sarcoma excreted the virus. A further study of the ratio of T cell helpers to suppressors in the men aged over 30 and a series of age matched non-excreting homosexual control or heterosexual men showed that those excreting cytomegalovirus in their seminal fluid had statistically lower ratios (all <0.77) than the controls (p <0.05). Excretion of cytomegalovirus may be related to re-emergence of latent infection in immunosuppressed homosexual men.
UR - http://www.scopus.com/inward/record.url?scp=0020608946&partnerID=8YFLogxK
U2 - 10.1136/bmj.286.6383.2010
DO - 10.1136/bmj.286.6383.2010
M3 - Journal article
C2 - 6307459
AN - SCOPUS:0020608946
VL - 286
SP - 2010
EP - 2012
JO - BMJ Innovations
JF - BMJ Innovations
SN - 2055-8074
IS - 6383
ER -
ID: 260895025