Secretin N-terminal hexapeptide potentiates insulin release in mouse islets
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Secretin N-terminal hexapeptide potentiates insulin release in mouse islets. / Kofod, Hans.
I: Regulatory Peptides, Bind 15, Nr. 3, 10.1986, s. 229-37.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Secretin N-terminal hexapeptide potentiates insulin release in mouse islets
AU - Kofod, Hans
PY - 1986/10
Y1 - 1986/10
N2 - Peptides representing the N-terminal part of secretin were synthesized and their effects tested on column-perifused isolated mouse pancreatic islets. Insulin release induced by D-glucose was potentiated by the two peptides His-Ser-Asp-Gly-Thr-Phe-OMe (S1-6) and Ser-Asp-Gly-Thr-Phe-OMe (S2-6). The consecutive smaller N-terminal peptides Asp-Gly-Thr-Phe-OMe (S3-6) and Gly-Thr-Phe-OMe (S4-6) had no effects while the dipeptide ester Thr-Phe-OMe (S5-6) also potentiated the release of insulin. The results suggest that the N-terminal part of secretin may be involved in the marked in vitro glucose-dependent insulin release induced by secretin.
AB - Peptides representing the N-terminal part of secretin were synthesized and their effects tested on column-perifused isolated mouse pancreatic islets. Insulin release induced by D-glucose was potentiated by the two peptides His-Ser-Asp-Gly-Thr-Phe-OMe (S1-6) and Ser-Asp-Gly-Thr-Phe-OMe (S2-6). The consecutive smaller N-terminal peptides Asp-Gly-Thr-Phe-OMe (S3-6) and Gly-Thr-Phe-OMe (S4-6) had no effects while the dipeptide ester Thr-Phe-OMe (S5-6) also potentiated the release of insulin. The results suggest that the N-terminal part of secretin may be involved in the marked in vitro glucose-dependent insulin release induced by secretin.
KW - Amino Acid Sequence
KW - Animals
KW - Glucose
KW - Insulin
KW - Islets of Langerhans
KW - Male
KW - Mice
KW - Mice, Inbred Strains
KW - Peptide Fragments
KW - Secretin
KW - Structure-Activity Relationship
M3 - Journal article
C2 - 3538223
VL - 15
SP - 229
EP - 237
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 3
ER -
ID: 45575228