Renal uptake and excretion of epidermal growth factor from plasma in the rat

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Standard

Renal uptake and excretion of epidermal growth factor from plasma in the rat. / Jørgensen, Per E.; Rasmussen, Torben N.; Olsen, Peter Skov; Raaberg, Lasse; Poulsen, Steen Seier; Nexø, Ebba.

I: Regulatory Peptides, Bind 28, Nr. 3, 21.05.1990, s. 273-280.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jørgensen, PE, Rasmussen, TN, Olsen, PS, Raaberg, L, Poulsen, SS & Nexø, E 1990, 'Renal uptake and excretion of epidermal growth factor from plasma in the rat', Regulatory Peptides, bind 28, nr. 3, s. 273-280. https://doi.org/10.1016/0167-0115(90)90025-R

APA

Jørgensen, P. E., Rasmussen, T. N., Olsen, P. S., Raaberg, L., Poulsen, S. S., & Nexø, E. (1990). Renal uptake and excretion of epidermal growth factor from plasma in the rat. Regulatory Peptides, 28(3), 273-280. https://doi.org/10.1016/0167-0115(90)90025-R

Vancouver

Jørgensen PE, Rasmussen TN, Olsen PS, Raaberg L, Poulsen SS, Nexø E. Renal uptake and excretion of epidermal growth factor from plasma in the rat. Regulatory Peptides. 1990 maj 21;28(3):273-280. https://doi.org/10.1016/0167-0115(90)90025-R

Author

Jørgensen, Per E. ; Rasmussen, Torben N. ; Olsen, Peter Skov ; Raaberg, Lasse ; Poulsen, Steen Seier ; Nexø, Ebba. / Renal uptake and excretion of epidermal growth factor from plasma in the rat. I: Regulatory Peptides. 1990 ; Bind 28, Nr. 3. s. 273-280.

Bibtex

@article{c831831cb6e64312acf1a9d145e3ce88,
title = "Renal uptake and excretion of epidermal growth factor from plasma in the rat",
abstract = "The rat excretes around 2 nmol epidermal growth factor (EGF) in the urine per 24 h. The urinary EGF might be derived from plasma and/or might be synthesized in the kidneys. We have used the rat to study the renal uptake and excretion of homologous EGF from plasma. I.v. injected 125I-EGF was removed from the circulation within a few minutes. 5 min after the injection, the kidneys contained 12% of the 125I-EGF. The kidneys seemed to degrade most of the 125I-EGF which they accumulated from blood, as only 4% of the injected label was excreted as intact 125I-EGF in the urine. The amount of endogenous EGF in plasma was under the detection limit of our enzyme-linked immunosorbent assay (0.03 nmol/l) and it remained so after bilateral nephrectomy. Even if plasma EGF was 0.03 nmol/l excretion of EGF from plasma could account for less than 5% of the urinary EGF. This study shows that the kidneys are able to accumulate EGF from plasma and excrete a part of it as intact EGF in the urine. However, excretion of immunoreactive EGF from plasma can only account for a minor part of the urinary EGF.",
keywords = "Blood, Epidermal growth factor, Kidney, Metabolism, Rat, Urine",
author = "J{\o}rgensen, {Per E.} and Rasmussen, {Torben N.} and Olsen, {Peter Skov} and Lasse Raaberg and Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1990",
month = may,
day = "21",
doi = "10.1016/0167-0115(90)90025-R",
language = "English",
volume = "28",
pages = "273--280",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Renal uptake and excretion of epidermal growth factor from plasma in the rat

AU - Jørgensen, Per E.

AU - Rasmussen, Torben N.

AU - Olsen, Peter Skov

AU - Raaberg, Lasse

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1990/5/21

Y1 - 1990/5/21

N2 - The rat excretes around 2 nmol epidermal growth factor (EGF) in the urine per 24 h. The urinary EGF might be derived from plasma and/or might be synthesized in the kidneys. We have used the rat to study the renal uptake and excretion of homologous EGF from plasma. I.v. injected 125I-EGF was removed from the circulation within a few minutes. 5 min after the injection, the kidneys contained 12% of the 125I-EGF. The kidneys seemed to degrade most of the 125I-EGF which they accumulated from blood, as only 4% of the injected label was excreted as intact 125I-EGF in the urine. The amount of endogenous EGF in plasma was under the detection limit of our enzyme-linked immunosorbent assay (0.03 nmol/l) and it remained so after bilateral nephrectomy. Even if plasma EGF was 0.03 nmol/l excretion of EGF from plasma could account for less than 5% of the urinary EGF. This study shows that the kidneys are able to accumulate EGF from plasma and excrete a part of it as intact EGF in the urine. However, excretion of immunoreactive EGF from plasma can only account for a minor part of the urinary EGF.

AB - The rat excretes around 2 nmol epidermal growth factor (EGF) in the urine per 24 h. The urinary EGF might be derived from plasma and/or might be synthesized in the kidneys. We have used the rat to study the renal uptake and excretion of homologous EGF from plasma. I.v. injected 125I-EGF was removed from the circulation within a few minutes. 5 min after the injection, the kidneys contained 12% of the 125I-EGF. The kidneys seemed to degrade most of the 125I-EGF which they accumulated from blood, as only 4% of the injected label was excreted as intact 125I-EGF in the urine. The amount of endogenous EGF in plasma was under the detection limit of our enzyme-linked immunosorbent assay (0.03 nmol/l) and it remained so after bilateral nephrectomy. Even if plasma EGF was 0.03 nmol/l excretion of EGF from plasma could account for less than 5% of the urinary EGF. This study shows that the kidneys are able to accumulate EGF from plasma and excrete a part of it as intact EGF in the urine. However, excretion of immunoreactive EGF from plasma can only account for a minor part of the urinary EGF.

KW - Blood

KW - Epidermal growth factor

KW - Kidney

KW - Metabolism

KW - Rat

KW - Urine

UR - http://www.scopus.com/inward/record.url?scp=0025231281&partnerID=8YFLogxK

U2 - 10.1016/0167-0115(90)90025-R

DO - 10.1016/0167-0115(90)90025-R

M3 - Journal article

C2 - 2377743

AN - SCOPUS:0025231281

VL - 28

SP - 273

EP - 280

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 3

ER -

ID: 199324358