Renal 123I-MIBG uptake before and after live-donor kidney transplantation
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Renal 123I-MIBG uptake before and after live-donor kidney transplantation. / Rasmussen, Thomas; Nijs, Robin de; Olsen, Lene Kjær; Kamper, Anne Lise; Bang, Lia Evi; Frimodt-Møller, Marie; Kelbæk, Henning; Sørensen, Søren Schwartz; Kjær, Andreas; Feldt-Rasmussen, Bo; Svendsen, Jesper Hastrup; Hasbak, Philip.
I: Diagnostics, Bind 10, Nr. 10, 802, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Renal 123I-MIBG uptake before and after live-donor kidney transplantation
AU - Rasmussen, Thomas
AU - Nijs, Robin de
AU - Olsen, Lene Kjær
AU - Kamper, Anne Lise
AU - Bang, Lia Evi
AU - Frimodt-Møller, Marie
AU - Kelbæk, Henning
AU - Sørensen, Søren Schwartz
AU - Kjær, Andreas
AU - Feldt-Rasmussen, Bo
AU - Svendsen, Jesper Hastrup
AU - Hasbak, Philip
PY - 2020
Y1 - 2020
N2 - Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.
AB - Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.
KW - I-MIBG scintigraphy
KW - Live kidney donor
KW - Renal nervous activity
KW - Renal transplantation
KW - Sympathetic nervous system
U2 - 10.3390/diagnostics10100802
DO - 10.3390/diagnostics10100802
M3 - Journal article
C2 - 33050245
AN - SCOPUS:85092714064
VL - 10
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 10
M1 - 802
ER -
ID: 250482241