TY - JOUR

T1 - Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis

T2 - A MASK-air study

AU - Sousa-Pinto, Bernardo

AU - Louis, Gilles

AU - Vieira, Rafael J.

AU - Czarlewski, Wienczyslawa

AU - Anto, Josep M.

AU - Amaral, Rita

AU - Sá-Sousa, Ana

AU - Brussino, Luisa

AU - Canonica, G. Walter

AU - Loureiro, Claudia Chaves

AU - Cruz, Alvaro A.

AU - Gemicioglu, Bilun

AU - Haahtela, Tari

AU - Kupczyk, Maciej

AU - Kvedariene, Violeta

AU - Larenas-Linnemann, Desirée E.

AU - Pham-Thi, Nhân

AU - Puggioni, Francesca

AU - Regateiro, Frederico S.

AU - Romantowski, Jan

AU - Sastre, Joaquin

AU - Scichilone, Nicola

AU - Taborda-Barata, Luis

AU - Ventura, Maria Teresa

AU - Agache, Ioana

AU - Bedbrook, Anna

AU - Benfante, Alida

AU - Bergmann, Karl C.

AU - Bosnic-Anticevich, Sinthia

AU - Bonini, Matteo

AU - Boulet, Louis Philippe

AU - Brusselle, Guy

AU - Buhl, Roland

AU - Cecchi, Lorenzo

AU - Charpin, Denis

AU - Costa, Elisio M.

AU - Del Giacco, Stefano

AU - Jutel, Marek

AU - Klimek, Ludger

AU - Kuna, Piotr

AU - Laune, Daniel

AU - Makela, Mika

AU - Morais-Almeida, Mario

AU - Nadif, Rachel

AU - Niedoszytko, Marek

AU - Papadopoulos, Nikolaos G.

AU - Papi, Alberto

AU - Pfaar, Oliver

AU - Rivero-Yeverino, Daniela

AU - Ulrik, Charlotte Suppli

AU - MASK-air think tank

N1 - Publisher Copyright: © 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

PY - 2024

Y1 - 2024

N2 - Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.

AB - Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.

KW - asthma

KW - diagnosis

KW - dyspnea

KW - mHealth

KW - wheezing

U2 - 10.1002/clt2.12358

DO - 10.1002/clt2.12358

M3 - Journal article

C2 - 38804596

AN - SCOPUS:85195109029

VL - 14

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

IS - 6

M1 - e12358

ER -