Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Telomeres generally shorten with age. An accelerated shortening of the telomeres has been linked to several age-related disorders. We hypothesized that the relative length of telomeres could discriminate between patients with late-onset Alzheimer's disease (AD) and vascular dementia (VaD). A quantitative real-time PCR method was used to calculate the relative telomere length in 76 age-matched and sex-matched, newly diagnosed late-onset AD or VaD patients recruited from our Memory Unit. No significant difference was found in the relative telomere length between AD and VaD cases neither in men (P=0.315) nor women (P=0.12). Thus, we could not confirm that the length of telomeres would predict which form of dementia, late-onset AD or VaD that develops.
Originalsprog | Engelsk |
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Tidsskrift | NeuroReport |
Vol/bind | 19 |
Udgave nummer | 12 |
Sider (fra-til) | 1199-202 |
Antal sider | 4 |
ISSN | 0959-4965 |
DOI | |
Status | Udgivet - 6 aug. 2008 |
Eksternt udgivet | Ja |
ID: 46848203