Regional longitudinal strain patterns according to left ventricular hypertrophy in the general population
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Regional longitudinal strain patterns according to left ventricular hypertrophy in the general population. / Frimodt-Moller, Katrine Emilie; Olsen, Flemming Javier; Biering-Sorensen, Sofie Reumert; Lassen, Mats Christian Hojbjerg; Mogelvang, Rasmus; Schnohr, Peter; Jensen, Gorm; Gislason, Gunnar; Marcus, Gregory Maurice; Biering-Sorensen, Tor.
I: European Heart Journal Cardiovascular Imaging, Bind 23, Nr. 11, 2022, s. 1436–1444.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Regional longitudinal strain patterns according to left ventricular hypertrophy in the general population
AU - Frimodt-Moller, Katrine Emilie
AU - Olsen, Flemming Javier
AU - Biering-Sorensen, Sofie Reumert
AU - Lassen, Mats Christian Hojbjerg
AU - Mogelvang, Rasmus
AU - Schnohr, Peter
AU - Jensen, Gorm
AU - Gislason, Gunnar
AU - Marcus, Gregory Maurice
AU - Biering-Sorensen, Tor
PY - 2022
Y1 - 2022
N2 - Aims A pattern of reduced basal longitudinal strain (BLS) is often observed with left ventricular (LV) hypertrophy (LVH). Whether this pattern is associated with poor outcome is unclear. We aimed to evaluate the prognostic value of regional longitudinal strain according to LV geometry. Methods and results We investigated participants in the 4th Copenhagen City Heart Study who had an echocardiogram with speckle tracking performed. Participants were stratified according to the presence of LVH (LV mass index >= 116 g/m(2) for men and >= 96 g/m(2) for women). The outcome was major adverse cardiovascular events (MACE) defined as a composite of myocardial infarction, heart failure, and/or cardiovascular death. The study population consisted of 1090 participants. Mean LVEF was 60% and 160 (15%) had LVH. During a median follow-up of 14.7 years, there were 137 events. Both BLS and midventricular strain, but not apical strain, became incrementally impaired in the spectrum from normal to hypertensives subjects without LVH, and to participants with hypertension and LVH. After multivariable adjustment, BLS and midventricular strain were independently associated with MACE in participants with LVH (BLS: HR 1.08, 95% CI 1.00-1.17, P = 0.041; midventricular strain: HR 1.10, 95% CI 1.00-1.21, P = 0.041) but not in participants without LVH (BLS: HR 0.96, 95% CI 0.90-1.01, P = 0.13; midventricular strain: HR 0.97, 95% CI 0.91-1.03, P = 0.36). Conclusion BLS and midventricular strain, but not apical strain, become incrementally impaired in the spectrum from normal geometry to LVH, and are independently associated with MACE in participants with LVH.
AB - Aims A pattern of reduced basal longitudinal strain (BLS) is often observed with left ventricular (LV) hypertrophy (LVH). Whether this pattern is associated with poor outcome is unclear. We aimed to evaluate the prognostic value of regional longitudinal strain according to LV geometry. Methods and results We investigated participants in the 4th Copenhagen City Heart Study who had an echocardiogram with speckle tracking performed. Participants were stratified according to the presence of LVH (LV mass index >= 116 g/m(2) for men and >= 96 g/m(2) for women). The outcome was major adverse cardiovascular events (MACE) defined as a composite of myocardial infarction, heart failure, and/or cardiovascular death. The study population consisted of 1090 participants. Mean LVEF was 60% and 160 (15%) had LVH. During a median follow-up of 14.7 years, there were 137 events. Both BLS and midventricular strain, but not apical strain, became incrementally impaired in the spectrum from normal to hypertensives subjects without LVH, and to participants with hypertension and LVH. After multivariable adjustment, BLS and midventricular strain were independently associated with MACE in participants with LVH (BLS: HR 1.08, 95% CI 1.00-1.17, P = 0.041; midventricular strain: HR 1.10, 95% CI 1.00-1.21, P = 0.041) but not in participants without LVH (BLS: HR 0.96, 95% CI 0.90-1.01, P = 0.13; midventricular strain: HR 0.97, 95% CI 0.91-1.03, P = 0.36). Conclusion BLS and midventricular strain, but not apical strain, become incrementally impaired in the spectrum from normal geometry to LVH, and are independently associated with MACE in participants with LVH.
KW - regional longitudinal strain
KW - speckle tracking echocardiography
KW - left ventricular hypertrophy
KW - strain imaging
KW - SPECKLE TRACKING ECHOCARDIOGRAPHY
KW - HYPERTENSIVE PATIENTS
KW - HEART-FAILURE
KW - MORTALITY
KW - DEFORMATION
KW - PREDICTION
KW - BASAL
U2 - 10.1093/ehjci/jeac118
DO - 10.1093/ehjci/jeac118
M3 - Journal article
C2 - 35762579
VL - 23
SP - 1436
EP - 1444
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 11
ER -
ID: 317370022