Regional cerebral blood flow in acute experimental allergic encephalomyelitis
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Regional cerebral blood flow in acute experimental allergic encephalomyelitis. / Juhler, M; Paulson, O B.
I: Brain Research, Bind 363, Nr. 2, 22.01.1986, s. 272-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Regional cerebral blood flow in acute experimental allergic encephalomyelitis
AU - Juhler, M
AU - Paulson, O B
PY - 1986/1/22
Y1 - 1986/1/22
N2 - Regional cerebral blood flow was studied in Lewis rats with fulminant acute experimental allergic encephalomyelitis (EAE). [14C]iodoantipyrine was used as a tracer. By employing a short experimental time and an infusion schedule producing an increasing arterial tracer concentration, the spatial resolution of the method was fine enough to detect focal increases in blood flow in the small central nervous system lesions (lymphocytic accumulations). An increase of flow of 100% in the lesions and a decrease of 50% in the cerebral cortex of EAE animals was statistically significant. In all other regions studied (deep cerebral structures, cerebellum), blood flow in EAE animals did not differ from the control values. The flow increase corresponding to the lesions may be due to inflammatory hyperemia. The cortical decrease in flow may be secondary to sensory motor impairment.
AB - Regional cerebral blood flow was studied in Lewis rats with fulminant acute experimental allergic encephalomyelitis (EAE). [14C]iodoantipyrine was used as a tracer. By employing a short experimental time and an infusion schedule producing an increasing arterial tracer concentration, the spatial resolution of the method was fine enough to detect focal increases in blood flow in the small central nervous system lesions (lymphocytic accumulations). An increase of flow of 100% in the lesions and a decrease of 50% in the cerebral cortex of EAE animals was statistically significant. In all other regions studied (deep cerebral structures, cerebellum), blood flow in EAE animals did not differ from the control values. The flow increase corresponding to the lesions may be due to inflammatory hyperemia. The cortical decrease in flow may be secondary to sensory motor impairment.
KW - Acute Disease
KW - Animals
KW - Antipyrine/analogs & derivatives
KW - Autoradiography
KW - Blood-Brain Barrier
KW - Brain/blood supply
KW - Cerebral Cortex/blood supply
KW - Encephalomyelitis, Autoimmune, Experimental/physiopathology
KW - Male
KW - Rats
KW - Rats, Inbred Lew
KW - Regional Blood Flow
KW - Thalamus/blood supply
U2 - 10.1016/0006-8993(86)91012-7
DO - 10.1016/0006-8993(86)91012-7
M3 - Journal article
C2 - 3484654
VL - 363
SP - 272
EP - 278
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -
ID: 275604937