Regional cerebral blood flow assessed by133Xe inhalation and emission tomography: Normal values
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Regional cerebral blood flow assessed by133Xe inhalation and emission tomography : Normal values. / Shirahata, Nobuyuki; Henriksen, Leif; Vorstrup, Sissel; Holm, Søren; Lauritzen, Martin; Paulson, Olaf B.; Lassen, Niels A.
I: Journal of Computer Assisted Tomography, Bind 9, Nr. 5, 01.01.1985, s. 861-866.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Regional cerebral blood flow assessed by133Xe inhalation and emission tomography
T2 - Normal values
AU - Shirahata, Nobuyuki
AU - Henriksen, Leif
AU - Vorstrup, Sissel
AU - Holm, Søren
AU - Lauritzen, Martin
AU - Paulson, Olaf B.
AU - Lassen, Niels A.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Regional cerebral blood flow (rCBF) in the cerebral hemispheres and the cerebellum was measured by single photon emission computed tomography with inhalation of133Xe in 39 normal volunteers at test. The goal of this study was to assess the normal flow pattern and its variations. Five parallel tomographic slices through the brain were recorded with a resolution element of 1.7 x 1.7 x 2.0 cm (full width at half maximum). The blood flow distribution showed that the predominantly gray matter areas displayed flow approximately double that of the predominantly white matter regions. The CBF distribution was practically symmetrical with a side-to-side difference averaging 1.4 ± 1.4 ml/100 g/min. This means that a difference exceeding 4.2 ml/100 g/min (approximately 9% of mean CBF) is abnormal with a confidence level of below 5%. The measured average CBF and cerebellar blood flow were 56 ± 7 and 54 ± 6 ml/100 g/min (mean ± 1 SD), respectively. A significant correlation was found between CBF and Pco2, and between CBF and age. Repeat measurements in an additional 30 subjects showed a day-to-day variability of -0.2 ± 6.4 ml/100 g/min of the difference between the first and the second measurement. This corresponds to random methodological and biological errors of 6.4/√2 = 4.6 ml/100 g/min and is a measure of the overall intraindividual variability. Xenon-133 tomography is atraumatic and affords rCBF images free of the superposition artifacts that practically invalidate the nontomographic approaches in the studies of cerebrovascular disease. The rCBF tomograms are blurred, particularly due to Compton scatter. Relative to this factor, the errors caused by local variations in the tissue:blood partition coefficient are less important.
AB - Regional cerebral blood flow (rCBF) in the cerebral hemispheres and the cerebellum was measured by single photon emission computed tomography with inhalation of133Xe in 39 normal volunteers at test. The goal of this study was to assess the normal flow pattern and its variations. Five parallel tomographic slices through the brain were recorded with a resolution element of 1.7 x 1.7 x 2.0 cm (full width at half maximum). The blood flow distribution showed that the predominantly gray matter areas displayed flow approximately double that of the predominantly white matter regions. The CBF distribution was practically symmetrical with a side-to-side difference averaging 1.4 ± 1.4 ml/100 g/min. This means that a difference exceeding 4.2 ml/100 g/min (approximately 9% of mean CBF) is abnormal with a confidence level of below 5%. The measured average CBF and cerebellar blood flow were 56 ± 7 and 54 ± 6 ml/100 g/min (mean ± 1 SD), respectively. A significant correlation was found between CBF and Pco2, and between CBF and age. Repeat measurements in an additional 30 subjects showed a day-to-day variability of -0.2 ± 6.4 ml/100 g/min of the difference between the first and the second measurement. This corresponds to random methodological and biological errors of 6.4/√2 = 4.6 ml/100 g/min and is a measure of the overall intraindividual variability. Xenon-133 tomography is atraumatic and affords rCBF images free of the superposition artifacts that practically invalidate the nontomographic approaches in the studies of cerebrovascular disease. The rCBF tomograms are blurred, particularly due to Compton scatter. Relative to this factor, the errors caused by local variations in the tissue:blood partition coefficient are less important.
KW - Brain
KW - Cerebral blood vessels
KW - Flow dynamics
KW - Gray matter
KW - Single photon emission computed tomography
KW - White
KW - Xenon
UR - http://www.scopus.com/inward/record.url?scp=0022259271&partnerID=8YFLogxK
U2 - 10.1097/00004728-198509000-00004
DO - 10.1097/00004728-198509000-00004
M3 - Journal article
C2 - 3875638
AN - SCOPUS:0022259271
VL - 9
SP - 861
EP - 866
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 5
ER -
ID: 201458133