Reduced cellular immune reactivity in healthy individuals during the malaria transmission season
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Reduced cellular immune reactivity in healthy individuals during the malaria transmission season. / Theander, T G; Hviid, L; Abu-Zeid, Y A; Abdulhadi, N H; Saeed, B O; Jakobsen, P H; Reimert, C M; Jepsen, S; Bayoumi, R A; Jensen, J B.
I: Immunology Letters, Bind 25, Nr. 1-3, 1990, s. 237-42.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Reduced cellular immune reactivity in healthy individuals during the malaria transmission season
AU - Theander, T G
AU - Hviid, L
AU - Abu-Zeid, Y A
AU - Abdulhadi, N H
AU - Saeed, B O
AU - Jakobsen, P H
AU - Reimert, C M
AU - Jepsen, S
AU - Bayoumi, R A
AU - Jensen, J B
N1 - Keywords: Adolescent; Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Child; Child, Preschool; Female; Humans; Lymphocyte Activation; Malaria; Male; Middle Aged; Phytohemagglutinins; Plasmodium; Protozoan Proteins; Seasons; Sudan; Tuberculin
PY - 1990
Y1 - 1990
N2 - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.
AB - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.
M3 - Journal article
C2 - 2283153
VL - 25
SP - 237
EP - 242
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 1-3
ER -
ID: 6748591