Reactivation of viral replication in anti-HBe positive chronic HBsAg carriers.
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Reactivation of viral replication in anti-HBe positive chronic HBsAg carriers. / Krogsgaard, K; Aldershvile, J; Kryger, Peter; Pedersen, C; Andersson, P; Dalbøge, H; Nielsen, Jens Ole; Hansson, B G.
I: Liver, Bind 10, Nr. 1, 1990, s. 54-58.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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T1 - Reactivation of viral replication in anti-HBe positive chronic HBsAg carriers.
AU - Krogsgaard, K
AU - Aldershvile, J
AU - Kryger, Peter
AU - Pedersen, C
AU - Andersson, P
AU - Dalbøge, H
AU - Nielsen, Jens Ole
AU - Hansson, B G
PY - 1990
Y1 - 1990
N2 - Reactivation of hepatitis B virus replication was investigated in an unselected group of 44 HBV DNA negative, anti-HBe positive chronic HBsAg carriers. Twenty-five patients (54%) were intravenous drug addicts and 7 (16%) were male homosexuals. Sixteen patients had evidence of delta infection and five of the seven male homosexuals had human immunodeficiency virus infection. The patients were followed for 1 to 180 months (median, 24 months) while HBV DNA negative, anti-HBe positive. Reactivation, defined as reappearance of HBV DNA or HBeAg, or both, was detected in six patients corresponding to an annual reactivation rate of 5%. Reactivation in four patients was detected by reversion to HBV DNA positivity only, whereas HBeAg/anti-HBe status remained unchanged. Two patients became both HBV DNA and HBeAg positive. None of the patients developed hepatitis-like symptoms and transaminase elevation was only observed in two patients. Reactivation in two patients was ascribed to human immunodeficiency virus infection and in one patient to chronic lymphatic leukaemia. It is concluded that HBV DNA seems to be superior to HBeAg in the detection of reactivation of HBV replication and that reactivation associated with clinical symptoms leading to progression in chronic liver disease is a rare event in the population studied.
AB - Reactivation of hepatitis B virus replication was investigated in an unselected group of 44 HBV DNA negative, anti-HBe positive chronic HBsAg carriers. Twenty-five patients (54%) were intravenous drug addicts and 7 (16%) were male homosexuals. Sixteen patients had evidence of delta infection and five of the seven male homosexuals had human immunodeficiency virus infection. The patients were followed for 1 to 180 months (median, 24 months) while HBV DNA negative, anti-HBe positive. Reactivation, defined as reappearance of HBV DNA or HBeAg, or both, was detected in six patients corresponding to an annual reactivation rate of 5%. Reactivation in four patients was detected by reversion to HBV DNA positivity only, whereas HBeAg/anti-HBe status remained unchanged. Two patients became both HBV DNA and HBeAg positive. None of the patients developed hepatitis-like symptoms and transaminase elevation was only observed in two patients. Reactivation in two patients was ascribed to human immunodeficiency virus infection and in one patient to chronic lymphatic leukaemia. It is concluded that HBV DNA seems to be superior to HBeAg in the detection of reactivation of HBV replication and that reactivation associated with clinical symptoms leading to progression in chronic liver disease is a rare event in the population studied.
M3 - Journal article
VL - 10
SP - 54
EP - 58
JO - Liver
JF - Liver
IS - 1
ER -
ID: 34124854