Rapid improvement of myasthenia gravis after plasma exchange

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Standard

Rapid improvement of myasthenia gravis after plasma exchange. / Nielsen, V K; Paulson, O B; Rosenkvist, J; Holsøe, E; Lefvert, A K.

I: Annals of Neurology, Bind 11, Nr. 2, 02.1982, s. 160-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, VK, Paulson, OB, Rosenkvist, J, Holsøe, E & Lefvert, AK 1982, 'Rapid improvement of myasthenia gravis after plasma exchange', Annals of Neurology, bind 11, nr. 2, s. 160-9. https://doi.org/10.1002/ana.410110209

APA

Nielsen, V. K., Paulson, O. B., Rosenkvist, J., Holsøe, E., & Lefvert, A. K. (1982). Rapid improvement of myasthenia gravis after plasma exchange. Annals of Neurology, 11(2), 160-9. https://doi.org/10.1002/ana.410110209

Vancouver

Nielsen VK, Paulson OB, Rosenkvist J, Holsøe E, Lefvert AK. Rapid improvement of myasthenia gravis after plasma exchange. Annals of Neurology. 1982 feb.;11(2):160-9. https://doi.org/10.1002/ana.410110209

Author

Nielsen, V K ; Paulson, O B ; Rosenkvist, J ; Holsøe, E ; Lefvert, A K. / Rapid improvement of myasthenia gravis after plasma exchange. I: Annals of Neurology. 1982 ; Bind 11, Nr. 2. s. 160-9.

Bibtex

@article{16dd61abafd9489d859531f444b408ca,
title = "Rapid improvement of myasthenia gravis after plasma exchange",
abstract = "Neuromuscular transmission and the staircase phenomenon in the adductor pollicis muscle were studied in six patients with myasthenia gravis before and 24 hours after single plasma exchanges given in short series over one to four weeks. An improvement in neuromuscular transmission was observed in all patients but one within 24 hours, suggesting that an immunological block of receptor sites is reversible or that acetylcholine receptors are rapidly resynthesized. In addition to a neuromuscular transmission defect, two of the patients also showed evidence of impaired excitation-contraction coupling with a negative staircase phenomenon and reduced posttetanic twitch potentiation. This condition became normal after plasma exchange, which may indicate that a reversible immunological impairment of the sarcoplasmic reticulum was present. Improvement lasted up to several months. The anti-acetylcholine receptor antibody titers were lowered in response to single plasma exchanges, but actual titer levels showed poor correlation with clinical and electrophysiological changes.",
keywords = "Action Potentials, Adolescent, Adult, Autoantibodies/analysis, Female, Humans, Male, Middle Aged, Muscle Contraction, Myasthenia Gravis/immunology, Neuromuscular Junction/physiology, Plasma Exchange, Synaptic Transmission",
author = "Nielsen, {V K} and Paulson, {O B} and J Rosenkvist and E Hols{\o}e and Lefvert, {A K}",
year = "1982",
month = feb,
doi = "10.1002/ana.410110209",
language = "English",
volume = "11",
pages = "160--9",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Rapid improvement of myasthenia gravis after plasma exchange

AU - Nielsen, V K

AU - Paulson, O B

AU - Rosenkvist, J

AU - Holsøe, E

AU - Lefvert, A K

PY - 1982/2

Y1 - 1982/2

N2 - Neuromuscular transmission and the staircase phenomenon in the adductor pollicis muscle were studied in six patients with myasthenia gravis before and 24 hours after single plasma exchanges given in short series over one to four weeks. An improvement in neuromuscular transmission was observed in all patients but one within 24 hours, suggesting that an immunological block of receptor sites is reversible or that acetylcholine receptors are rapidly resynthesized. In addition to a neuromuscular transmission defect, two of the patients also showed evidence of impaired excitation-contraction coupling with a negative staircase phenomenon and reduced posttetanic twitch potentiation. This condition became normal after plasma exchange, which may indicate that a reversible immunological impairment of the sarcoplasmic reticulum was present. Improvement lasted up to several months. The anti-acetylcholine receptor antibody titers were lowered in response to single plasma exchanges, but actual titer levels showed poor correlation with clinical and electrophysiological changes.

AB - Neuromuscular transmission and the staircase phenomenon in the adductor pollicis muscle were studied in six patients with myasthenia gravis before and 24 hours after single plasma exchanges given in short series over one to four weeks. An improvement in neuromuscular transmission was observed in all patients but one within 24 hours, suggesting that an immunological block of receptor sites is reversible or that acetylcholine receptors are rapidly resynthesized. In addition to a neuromuscular transmission defect, two of the patients also showed evidence of impaired excitation-contraction coupling with a negative staircase phenomenon and reduced posttetanic twitch potentiation. This condition became normal after plasma exchange, which may indicate that a reversible immunological impairment of the sarcoplasmic reticulum was present. Improvement lasted up to several months. The anti-acetylcholine receptor antibody titers were lowered in response to single plasma exchanges, but actual titer levels showed poor correlation with clinical and electrophysiological changes.

KW - Action Potentials

KW - Adolescent

KW - Adult

KW - Autoantibodies/analysis

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Contraction

KW - Myasthenia Gravis/immunology

KW - Neuromuscular Junction/physiology

KW - Plasma Exchange

KW - Synaptic Transmission

U2 - 10.1002/ana.410110209

DO - 10.1002/ana.410110209

M3 - Journal article

C2 - 6280584

VL - 11

SP - 160

EP - 169

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 2

ER -

ID: 276072885