Protein-carbohydrate supplements improve muscle protein balance in muscular dystrophy patients after endurance exercise: a placebo-controlled crossover study
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Protein-carbohydrate supplements improve muscle protein balance in muscular dystrophy patients after endurance exercise : a placebo-controlled crossover study. / Andersen, Grete; Ørngreen, Mette C; Preisler, Nicolai; Jeppesen, Tina D; Krag, Thomas O; Hauerslev, Simon; van Hall, Gerrit; Vissing, John.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 308, Nr. 2, 15.01.2015, s. R123-R130.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Protein-carbohydrate supplements improve muscle protein balance in muscular dystrophy patients after endurance exercise
T2 - a placebo-controlled crossover study
AU - Andersen, Grete
AU - Ørngreen, Mette C
AU - Preisler, Nicolai
AU - Jeppesen, Tina D
AU - Krag, Thomas O
AU - Hauerslev, Simon
AU - van Hall, Gerrit
AU - Vissing, John
N1 - Copyright © 2015 the American Physiological Society.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - In healthy individuals, postexercise protein supplementation increases muscle protein anabolism. In patients with muscular dystrophies, aerobic exercise improves muscle function, but the effect of exercise on muscle protein balance is unknown. Therefore, we investigated 1) muscle protein balance before, during, and after exercise and 2) the effect of postexercise protein-carbohydrate supplementation on muscle protein balance in patients with muscular dystrophies. In 17 patients [7 women and 10 men, aged 33 ± 11 yr (18-52), body mass index: 22 ± 3 kg/m(2) (16-26)] and 8 healthy matched controls [3 women and 5 men, age 33 ± 13 years (19-54), body mass index: 23 ± 3 kg/m(2) (19-27)], muscle protein synthesis, breakdown, and fractional synthesis rates (FSR) were measured across the leg using tracer dilution methodology on two occasions, with and without oral postexercise protein-carbohydrate supplementation. In patients, muscle protein breakdown increased in the recovery period (11 ± 1 μmol phenylalanine/min) vs. rest (8 ± 1 μmol phenylalanine/min, P = 0.02), enhancing net muscle protein loss. In contrast, postexercise protein-carbohydrate supplementation reduced protein breakdown, abolished net muscle protein loss, and increased the muscle FSR in patients (0.04 to 0.06%/h; P = 0.03). In conclusion, postexercise protein-carbohydrate supplementation reduces skeletal mixed-muscle protein breakdown, enhances FSR, resulting in a reduced net muscle loss in patients with muscular dystrophies. The findings suggest that postexercise protein-carbohydrate supplementation could be an important add-on to exercise training therapy in muscular dystrophies, and long-term studies of postexercise protein-carbohydrate supplementation are warranted in these conditions.
AB - In healthy individuals, postexercise protein supplementation increases muscle protein anabolism. In patients with muscular dystrophies, aerobic exercise improves muscle function, but the effect of exercise on muscle protein balance is unknown. Therefore, we investigated 1) muscle protein balance before, during, and after exercise and 2) the effect of postexercise protein-carbohydrate supplementation on muscle protein balance in patients with muscular dystrophies. In 17 patients [7 women and 10 men, aged 33 ± 11 yr (18-52), body mass index: 22 ± 3 kg/m(2) (16-26)] and 8 healthy matched controls [3 women and 5 men, age 33 ± 13 years (19-54), body mass index: 23 ± 3 kg/m(2) (19-27)], muscle protein synthesis, breakdown, and fractional synthesis rates (FSR) were measured across the leg using tracer dilution methodology on two occasions, with and without oral postexercise protein-carbohydrate supplementation. In patients, muscle protein breakdown increased in the recovery period (11 ± 1 μmol phenylalanine/min) vs. rest (8 ± 1 μmol phenylalanine/min, P = 0.02), enhancing net muscle protein loss. In contrast, postexercise protein-carbohydrate supplementation reduced protein breakdown, abolished net muscle protein loss, and increased the muscle FSR in patients (0.04 to 0.06%/h; P = 0.03). In conclusion, postexercise protein-carbohydrate supplementation reduces skeletal mixed-muscle protein breakdown, enhances FSR, resulting in a reduced net muscle loss in patients with muscular dystrophies. The findings suggest that postexercise protein-carbohydrate supplementation could be an important add-on to exercise training therapy in muscular dystrophies, and long-term studies of postexercise protein-carbohydrate supplementation are warranted in these conditions.
KW - Adolescent
KW - Adult
KW - Cross-Over Studies
KW - Dietary Carbohydrates
KW - Dietary Proteins
KW - Exercise
KW - Exercise Therapy
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Muscle Proteins
KW - Muscle, Skeletal
KW - Muscular Dystrophies
KW - Time
KW - Young Adult
U2 - 10.1152/ajpregu.00321.2014
DO - 10.1152/ajpregu.00321.2014
M3 - Journal article
C2 - 25411362
VL - 308
SP - R123-R130
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 2
ER -
ID: 135220458