Prognostic value of right ventricular echocardiographic measures in patients with heart failure with reduced ejection fraction
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Prognostic value of right ventricular echocardiographic measures in patients with heart failure with reduced ejection fraction. / Lundorff, Ingrid Josefine; Sengeløv, Morten; Pedersen, Sune; Modin, Daniel; Bruun, Niels Eske; Fritz-Hansen, Thomas; Biering-Sørensen, Tor; Godsk Jørgensen, Peter.
I: Journal of Clinical Ultrasound, Bind 49, Nr. 9, 2021, s. 903-913.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prognostic value of right ventricular echocardiographic measures in patients with heart failure with reduced ejection fraction
AU - Lundorff, Ingrid Josefine
AU - Sengeløv, Morten
AU - Pedersen, Sune
AU - Modin, Daniel
AU - Bruun, Niels Eske
AU - Fritz-Hansen, Thomas
AU - Biering-Sørensen, Tor
AU - Godsk Jørgensen, Peter
N1 - Publisher Copyright: © 2021 Wiley Periodicals LLC.
PY - 2021
Y1 - 2021
N2 - Purpose: Right ventricular (RV) dysfunction is associated with poor outcome in patients with heart failure. In order to better predict mortality in this patient group we wanted to compare the prognostic value of conventional and advanced RV echocardiographic measures. Methods: Echocardiographic examinations were retrieved from 701 patients. End point was all-cause mortality and follow-up 100%. RV parameters were measured offline in accordance with current guidelines. Speckle tracking was derived using the algorithm originally designed for the left ventricle. Results: During follow-up (median: 39 months) 118 patients (16.8%) died. RV global longitudinal strain (GLS) and RV free wall strain (FWS) remained associated with mortality after multivariable adjustment independent of Tricuspid annular plane systolic excursion (TAPSE) (RV GLS: HR 1.07, 95%CI 1.02–1.13, p = 0.010, per 1% decrease) (RV FWS: HR 1.05, 95%CI 1.01–1.09, p = 0.010, per 1% decrease). This seemed to be caused by significant associations in men. All RV estimates provided prognostic information incremental to established risk factors and significantly increased C-statistics. Conclusions: RV GLS and FWS were associated with mortality in HFrEF patients after multivariable adjustment independent of TAPSE. TAPSE, however, remained as the strongest prognosticator in women. More research is needed to identify whether speckle tracking could be superior to conventional RV measures in identifying HFrEF patients with poor outcome.
AB - Purpose: Right ventricular (RV) dysfunction is associated with poor outcome in patients with heart failure. In order to better predict mortality in this patient group we wanted to compare the prognostic value of conventional and advanced RV echocardiographic measures. Methods: Echocardiographic examinations were retrieved from 701 patients. End point was all-cause mortality and follow-up 100%. RV parameters were measured offline in accordance with current guidelines. Speckle tracking was derived using the algorithm originally designed for the left ventricle. Results: During follow-up (median: 39 months) 118 patients (16.8%) died. RV global longitudinal strain (GLS) and RV free wall strain (FWS) remained associated with mortality after multivariable adjustment independent of Tricuspid annular plane systolic excursion (TAPSE) (RV GLS: HR 1.07, 95%CI 1.02–1.13, p = 0.010, per 1% decrease) (RV FWS: HR 1.05, 95%CI 1.01–1.09, p = 0.010, per 1% decrease). This seemed to be caused by significant associations in men. All RV estimates provided prognostic information incremental to established risk factors and significantly increased C-statistics. Conclusions: RV GLS and FWS were associated with mortality in HFrEF patients after multivariable adjustment independent of TAPSE. TAPSE, however, remained as the strongest prognosticator in women. More research is needed to identify whether speckle tracking could be superior to conventional RV measures in identifying HFrEF patients with poor outcome.
KW - 2DSTE
KW - echocardiography
KW - heart failure
KW - right ventricle
KW - speckle tracking
U2 - 10.1002/jcu.23050
DO - 10.1002/jcu.23050
M3 - Journal article
C2 - 34337754
AN - SCOPUS:85111642980
VL - 49
SP - 903
EP - 913
JO - Journal of Clinical Ultrasound
JF - Journal of Clinical Ultrasound
SN - 0091-2751
IS - 9
ER -
ID: 276389953