Prognostic value of cardiac time intervals measured by tissue Doppler imaging M-mode in the general population
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
ABSTRACT
Objective Tissue Doppler imaging (TDI) M-mode
through the mitral leaflet is an easy and precise method
to estimate the cardiac time intervals. The aim was to
evaluate the usability of the cardiac time intervals in
predicting major cardiovascular events (MACE) in the
general population.
Methods In a large prospective community-based study,
cardiac function was evaluated in 1915 participants by
both conventional echocardiography and TDI. The cardiac
time intervals, including the isovolumic relaxation time
(IVRT), isovolumic contraction time (IVCT) and ejection time
(ET), were obtained by TDI M-mode through the mitral
leaflet. IVCT/ET, IVRT/ET and the myocardial performance
index (MPI=(IVRT+IVCT)/ET) were calculated.
Results During follow-up (median 10.8 years), 383
(20%) participants reached the combined endpoint MACE
(ischaemic heart disease, heart failure or cardiac death).
After multivariable adjustment for clinical predictors and
conventional echocardiography, only the combined
indexes, including information on both systolic and diastolic
performance (IVRT/ET and MPI), remained significant
prognosticators (p<0.05 for both). Adding IVRT/ET or MPI
to a model already including all other echocardiographic
parameters resulted in a significant increase in the cstatistics
(0.76 vs 0.75 p<0.01 for both). IVRT/ET or MPI
improved reclassification significantly when added to the
clinical predictors (p<0.05 for both).
Conclusions In the general population, the combined
cardiac time intervals that include information on both
systolic and diastolic function in one index (IVRT/ET and
MPI) are not only powerful and independent predictors of
future MACE, but provide additional prognostic information
to clinical and conventional echocardiographic measures of
systolic and diastolic function.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Heart |
Vol/bind | 101 |
Udgave nummer | 12 |
Sider (fra-til) | 954-60 |
Antal sider | 7 |
ISSN | 1355-6037 |
DOI | |
Status | Udgivet - jun. 2015 |
ID: 159107803