Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder. / Østergaard, Søren D.; Trabjerg, Betina B.; Als, Thomas D.; Climent, Clara Albiñana; Privé, Florian; Vilhjálmsson, Bjarni Jóhann; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hougaard, David M.; Nordentoft, Merete; Werge, Thomas; Demontis, Ditte; Mortensen, Preben B.; Børglum, Anders D.; Mors, Ole; Agerbo, Esben.

I: Translational Psychiatry, Bind 10, Nr. 1, 335, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Østergaard, SD, Trabjerg, BB, Als, TD, Climent, CA, Privé, F, Vilhjálmsson, BJ, Bækvad-Hansen, M, Bybjerg-Grauholm, J, Hougaard, DM, Nordentoft, M, Werge, T, Demontis, D, Mortensen, PB, Børglum, AD, Mors, O & Agerbo, E 2020, 'Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder', Translational Psychiatry, bind 10, nr. 1, 335. https://doi.org/10.1038/s41398-020-01019-6

APA

Østergaard, S. D., Trabjerg, B. B., Als, T. D., Climent, C. A., Privé, F., Vilhjálmsson, B. J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Nordentoft, M., Werge, T., Demontis, D., Mortensen, P. B., Børglum, A. D., Mors, O., & Agerbo, E. (2020). Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder. Translational Psychiatry, 10(1), [335]. https://doi.org/10.1038/s41398-020-01019-6

Vancouver

Østergaard SD, Trabjerg BB, Als TD, Climent CA, Privé F, Vilhjálmsson BJ o.a. Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder. Translational Psychiatry. 2020;10(1). 335. https://doi.org/10.1038/s41398-020-01019-6

Author

Østergaard, Søren D. ; Trabjerg, Betina B. ; Als, Thomas D. ; Climent, Clara Albiñana ; Privé, Florian ; Vilhjálmsson, Bjarni Jóhann ; Bækvad-Hansen, Marie ; Bybjerg-Grauholm, Jonas ; Hougaard, David M. ; Nordentoft, Merete ; Werge, Thomas ; Demontis, Ditte ; Mortensen, Preben B. ; Børglum, Anders D. ; Mors, Ole ; Agerbo, Esben. / Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder. I: Translational Psychiatry. 2020 ; Bind 10, Nr. 1.

Bibtex

@article{883af13efc90472b80a8750bdad30308,
title = "Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder",
abstract = "The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn population-based controls. These 33,872 cohort members were genotyped on the Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated the polygenic risk score (PRS) for ADHD and extracted register data regarding the following risk factors pertaining to the psychosocial environment for each cohort member at the time of birth: maternal/paternal history of mental disorders, maternal/paternal education, maternal/paternal work status, and maternal/paternal income. We used logistic regression analyses to assess the main effects of the PRS for ADHD and the psychosocial environment on the risk of ADHD. Subsequently, we evaluated whether the effect of the PRS and the psychosocial environment act independently or in interaction upon the risk of ADHD. We found that ADHD was strongly associated with the PRS (odds ratio: 6.03, 95%CI: 4.74–7.70 for highest vs. lowest 2% liability). All risk factors pertaining to the psychosocial environment were associated with an increased risk of ADHD. These associations were only slightly attenuated after mutual adjustments. We found no statistically significant interaction between the polygenic liability and the psychosocial environment upon the risk of ADHD. In conclusion, we found main effects of both polygenic liability and risk factors pertaining to the psychosocial environment on the risk of ADHD—in the expected direction.",
author = "{\O}stergaard, {S{\o}ren D.} and Trabjerg, {Betina B.} and Als, {Thomas D.} and Climent, {Clara Albi{\~n}ana} and Florian Priv{\'e} and Vilhj{\'a}lmsson, {Bjarni J{\'o}hann} and Marie B{\ae}kvad-Hansen and Jonas Bybjerg-Grauholm and Hougaard, {David M.} and Merete Nordentoft and Thomas Werge and Ditte Demontis and Mortensen, {Preben B.} and B{\o}rglum, {Anders D.} and Ole Mors and Esben Agerbo",
year = "2020",
doi = "10.1038/s41398-020-01019-6",
language = "English",
volume = "10",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder

AU - Østergaard, Søren D.

AU - Trabjerg, Betina B.

AU - Als, Thomas D.

AU - Climent, Clara Albiñana

AU - Privé, Florian

AU - Vilhjálmsson, Bjarni Jóhann

AU - Bækvad-Hansen, Marie

AU - Bybjerg-Grauholm, Jonas

AU - Hougaard, David M.

AU - Nordentoft, Merete

AU - Werge, Thomas

AU - Demontis, Ditte

AU - Mortensen, Preben B.

AU - Børglum, Anders D.

AU - Mors, Ole

AU - Agerbo, Esben

PY - 2020

Y1 - 2020

N2 - The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn population-based controls. These 33,872 cohort members were genotyped on the Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated the polygenic risk score (PRS) for ADHD and extracted register data regarding the following risk factors pertaining to the psychosocial environment for each cohort member at the time of birth: maternal/paternal history of mental disorders, maternal/paternal education, maternal/paternal work status, and maternal/paternal income. We used logistic regression analyses to assess the main effects of the PRS for ADHD and the psychosocial environment on the risk of ADHD. Subsequently, we evaluated whether the effect of the PRS and the psychosocial environment act independently or in interaction upon the risk of ADHD. We found that ADHD was strongly associated with the PRS (odds ratio: 6.03, 95%CI: 4.74–7.70 for highest vs. lowest 2% liability). All risk factors pertaining to the psychosocial environment were associated with an increased risk of ADHD. These associations were only slightly attenuated after mutual adjustments. We found no statistically significant interaction between the polygenic liability and the psychosocial environment upon the risk of ADHD. In conclusion, we found main effects of both polygenic liability and risk factors pertaining to the psychosocial environment on the risk of ADHD—in the expected direction.

AB - The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn population-based controls. These 33,872 cohort members were genotyped on the Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated the polygenic risk score (PRS) for ADHD and extracted register data regarding the following risk factors pertaining to the psychosocial environment for each cohort member at the time of birth: maternal/paternal history of mental disorders, maternal/paternal education, maternal/paternal work status, and maternal/paternal income. We used logistic regression analyses to assess the main effects of the PRS for ADHD and the psychosocial environment on the risk of ADHD. Subsequently, we evaluated whether the effect of the PRS and the psychosocial environment act independently or in interaction upon the risk of ADHD. We found that ADHD was strongly associated with the PRS (odds ratio: 6.03, 95%CI: 4.74–7.70 for highest vs. lowest 2% liability). All risk factors pertaining to the psychosocial environment were associated with an increased risk of ADHD. These associations were only slightly attenuated after mutual adjustments. We found no statistically significant interaction between the polygenic liability and the psychosocial environment upon the risk of ADHD. In conclusion, we found main effects of both polygenic liability and risk factors pertaining to the psychosocial environment on the risk of ADHD—in the expected direction.

U2 - 10.1038/s41398-020-01019-6

DO - 10.1038/s41398-020-01019-6

M3 - Journal article

C2 - 33009369

AN - SCOPUS:85091842443

VL - 10

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 335

ER -

ID: 261151932