Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Platelet transfusions in adult thrombocytopenic ICU patients : Protocol for a sub-study of the PLOT-ICU cohort. / Anthon, Carl Thomas; Pène, Frédéric; Perner, Anders; Azoulay, Elie; Puxty, Kathryn; Van De Louw, Andry; Chawla, Sanjay; Castro, Pedro; Povoa, Pedro; Coelho, Luis; Metaxa, Victoria; Kochanek, Matthias; Liebregts, Tobias; Kander, Thomas; Sivula, Mirka; Møller, Morten Hylander; Russell, Lene.

I: Acta Anaesthesiologica Scandinavica, Bind 68, Nr. 3, 2024, s. 434-440.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Anthon, CT, Pène, F, Perner, A, Azoulay, E, Puxty, K, Van De Louw, A, Chawla, S, Castro, P, Povoa, P, Coelho, L, Metaxa, V, Kochanek, M, Liebregts, T, Kander, T, Sivula, M, Møller, MH & Russell, L 2024, 'Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort', Acta Anaesthesiologica Scandinavica, bind 68, nr. 3, s. 434-440. https://doi.org/10.1111/aas.14365

APA

Anthon, C. T., Pène, F., Perner, A., Azoulay, E., Puxty, K., Van De Louw, A., Chawla, S., Castro, P., Povoa, P., Coelho, L., Metaxa, V., Kochanek, M., Liebregts, T., Kander, T., Sivula, M., Møller, M. H., & Russell, L. (2024). Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort. Acta Anaesthesiologica Scandinavica, 68(3), 434-440. https://doi.org/10.1111/aas.14365

Vancouver

Anthon CT, Pène F, Perner A, Azoulay E, Puxty K, Van De Louw A o.a. Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort. Acta Anaesthesiologica Scandinavica. 2024;68(3):434-440. https://doi.org/10.1111/aas.14365

Author

Anthon, Carl Thomas ; Pène, Frédéric ; Perner, Anders ; Azoulay, Elie ; Puxty, Kathryn ; Van De Louw, Andry ; Chawla, Sanjay ; Castro, Pedro ; Povoa, Pedro ; Coelho, Luis ; Metaxa, Victoria ; Kochanek, Matthias ; Liebregts, Tobias ; Kander, Thomas ; Sivula, Mirka ; Møller, Morten Hylander ; Russell, Lene. / Platelet transfusions in adult thrombocytopenic ICU patients : Protocol for a sub-study of the PLOT-ICU cohort. I: Acta Anaesthesiologica Scandinavica. 2024 ; Bind 68, Nr. 3. s. 434-440.

Bibtex

@article{8cf341dabc31405fb928e6bc98070b9e,
title = "Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub-study of the PLOT-ICU cohort",
abstract = "Introduction: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia. Methods: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the {\textquoteleft}Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU){\textquoteright}. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis-derived versus pooled whole-blood-derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight-based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell- and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow-up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively. Conclusions: The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT-ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.",
keywords = "critical care, intensive care unit, platelet transfusions, thrombocytopenia",
author = "Anthon, {Carl Thomas} and Fr{\'e}d{\'e}ric P{\`e}ne and Anders Perner and Elie Azoulay and Kathryn Puxty and {Van De Louw}, Andry and Sanjay Chawla and Pedro Castro and Pedro Povoa and Luis Coelho and Victoria Metaxa and Matthias Kochanek and Tobias Liebregts and Thomas Kander and Mirka Sivula and M{\o}ller, {Morten Hylander} and Lene Russell",
note = "Publisher Copyright: {\textcopyright} 2023 Acta Anaesthesiologica Scandinavica Foundation.",
year = "2024",
doi = "10.1111/aas.14365",
language = "English",
volume = "68",
pages = "434--440",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Platelet transfusions in adult thrombocytopenic ICU patients

T2 - Protocol for a sub-study of the PLOT-ICU cohort

AU - Anthon, Carl Thomas

AU - Pène, Frédéric

AU - Perner, Anders

AU - Azoulay, Elie

AU - Puxty, Kathryn

AU - Van De Louw, Andry

AU - Chawla, Sanjay

AU - Castro, Pedro

AU - Povoa, Pedro

AU - Coelho, Luis

AU - Metaxa, Victoria

AU - Kochanek, Matthias

AU - Liebregts, Tobias

AU - Kander, Thomas

AU - Sivula, Mirka

AU - Møller, Morten Hylander

AU - Russell, Lene

N1 - Publisher Copyright: © 2023 Acta Anaesthesiologica Scandinavica Foundation.

PY - 2024

Y1 - 2024

N2 - Introduction: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia. Methods: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the ‘Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)’. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis-derived versus pooled whole-blood-derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight-based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell- and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow-up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively. Conclusions: The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT-ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.

AB - Introduction: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia. Methods: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the ‘Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)’. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis-derived versus pooled whole-blood-derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight-based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell- and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow-up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively. Conclusions: The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT-ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.

KW - critical care

KW - intensive care unit

KW - platelet transfusions

KW - thrombocytopenia

U2 - 10.1111/aas.14365

DO - 10.1111/aas.14365

M3 - Journal article

C2 - 38115558

AN - SCOPUS:85180233480

VL - 68

SP - 434

EP - 440

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 3

ER -

ID: 384656841