Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals

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Standard

Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals. / Knudsen, Andreas; Katzenstein, Terese L; Benfield, Thomas; Jørgensen, Niklas R; Kronborg, Gitte; Gerstoft, Jan; Obel, Niels; Kjær, Andreas; Lebech, Anne-Mette.

I: AIDS, Bind 28, Nr. 8, 2014, s. 1171-1179.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Knudsen, A, Katzenstein, TL, Benfield, T, Jørgensen, NR, Kronborg, G, Gerstoft, J, Obel, N, Kjær, A & Lebech, A-M 2014, 'Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals', AIDS, bind 28, nr. 8, s. 1171-1179. https://doi.org/10.1097/QAD.0000000000000247

APA

Knudsen, A., Katzenstein, T. L., Benfield, T., Jørgensen, N. R., Kronborg, G., Gerstoft, J., Obel, N., Kjær, A., & Lebech, A-M. (2014). Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals. AIDS, 28(8), 1171-1179. https://doi.org/10.1097/QAD.0000000000000247

Vancouver

Knudsen A, Katzenstein TL, Benfield T, Jørgensen NR, Kronborg G, Gerstoft J o.a. Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals. AIDS. 2014;28(8):1171-1179. https://doi.org/10.1097/QAD.0000000000000247

Author

Knudsen, Andreas ; Katzenstein, Terese L ; Benfield, Thomas ; Jørgensen, Niklas R ; Kronborg, Gitte ; Gerstoft, Jan ; Obel, Niels ; Kjær, Andreas ; Lebech, Anne-Mette. / Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals. I: AIDS. 2014 ; Bind 28, Nr. 8. s. 1171-1179.

Bibtex

@article{75650c6d2f804a79847b43451fa17cc0,
title = "Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals",
abstract = "OBJECTIVES: Biomarkers of endothelial dysfunction, inflammation and coagulation are associated with atherosclerosis and cardiovascular disease, but their association and possible predictive value remain controversial among HIV-1-infected individuals. We sought to investigate the association of seven biomarkers with first-time myocardial infarction (MI) in an HIV-1-infected population.DESIGN: A matched case-control study of 54 cases and 54 controls.METHODS: We compared 54 HIV-1-infected patients with verified first-time MI and 54 HIV-1-infected controls matched for age, duration of antiretroviral therapy, sex, smoking and no known cardiovascular disease. Levels of high-sensitivity C-reactive protein, soluble endothelial selectin, soluble vascular cell adhesion molecule, soluble intercellular adhesion molecule, matrix metalloprotease 9, myeloperoxidase, and plasminogen activator inhibitor 1 (PAI-1) were measured using a Luminex assay in plasma samples from routine visits both 12 and 2 months prior to the case patient's MI.RESULTS: The two groups had similar HIV characteristics and traditional cardiovascular risk factors. In univariate analysis, PAI-1 levels were associated with MI, whereas none of the other markers showed any association.In multivariate analyses adjusting for the D:A:D risk score, HIV viral load and high-sensitivity C-reactive protein, PAI-1 levels in the highest quartile were associated with a six to seven-fold increased risk of MI in both samples.CONCLUSION: High levels of PAI-1 were associated with risk of first-time MI in HIV-1-infected individuals independently of cardiovascular risk factors, HIV parameters and antiretroviral therapy. Therefore PAI-1 may be used for risk stratification and prediction of CHD, but further studies are needed.",
keywords = "Adult, Biological Markers, C-Reactive Protein, Case-Control Studies, Cell Adhesion Molecules, Female, HIV Infections, HIV-1, Humans, Male, Matrix Metalloproteinase 9, Middle Aged, Myocardial Infarction, Peroxidase, Plasminogen Activator Inhibitor 1, Risk Factors, Selectins, Vascular Cell Adhesion Molecule-1, Viral Load",
author = "Andreas Knudsen and Katzenstein, {Terese L} and Thomas Benfield and J{\o}rgensen, {Niklas R} and Gitte Kronborg and Jan Gerstoft and Niels Obel and Andreas Kj{\ae}r and Anne-Mette Lebech",
year = "2014",
doi = "10.1097/QAD.0000000000000247",
language = "English",
volume = "28",
pages = "1171--1179",
journal = "AIDS",
issn = "1350-2840",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals

AU - Knudsen, Andreas

AU - Katzenstein, Terese L

AU - Benfield, Thomas

AU - Jørgensen, Niklas R

AU - Kronborg, Gitte

AU - Gerstoft, Jan

AU - Obel, Niels

AU - Kjær, Andreas

AU - Lebech, Anne-Mette

PY - 2014

Y1 - 2014

N2 - OBJECTIVES: Biomarkers of endothelial dysfunction, inflammation and coagulation are associated with atherosclerosis and cardiovascular disease, but their association and possible predictive value remain controversial among HIV-1-infected individuals. We sought to investigate the association of seven biomarkers with first-time myocardial infarction (MI) in an HIV-1-infected population.DESIGN: A matched case-control study of 54 cases and 54 controls.METHODS: We compared 54 HIV-1-infected patients with verified first-time MI and 54 HIV-1-infected controls matched for age, duration of antiretroviral therapy, sex, smoking and no known cardiovascular disease. Levels of high-sensitivity C-reactive protein, soluble endothelial selectin, soluble vascular cell adhesion molecule, soluble intercellular adhesion molecule, matrix metalloprotease 9, myeloperoxidase, and plasminogen activator inhibitor 1 (PAI-1) were measured using a Luminex assay in plasma samples from routine visits both 12 and 2 months prior to the case patient's MI.RESULTS: The two groups had similar HIV characteristics and traditional cardiovascular risk factors. In univariate analysis, PAI-1 levels were associated with MI, whereas none of the other markers showed any association.In multivariate analyses adjusting for the D:A:D risk score, HIV viral load and high-sensitivity C-reactive protein, PAI-1 levels in the highest quartile were associated with a six to seven-fold increased risk of MI in both samples.CONCLUSION: High levels of PAI-1 were associated with risk of first-time MI in HIV-1-infected individuals independently of cardiovascular risk factors, HIV parameters and antiretroviral therapy. Therefore PAI-1 may be used for risk stratification and prediction of CHD, but further studies are needed.

AB - OBJECTIVES: Biomarkers of endothelial dysfunction, inflammation and coagulation are associated with atherosclerosis and cardiovascular disease, but their association and possible predictive value remain controversial among HIV-1-infected individuals. We sought to investigate the association of seven biomarkers with first-time myocardial infarction (MI) in an HIV-1-infected population.DESIGN: A matched case-control study of 54 cases and 54 controls.METHODS: We compared 54 HIV-1-infected patients with verified first-time MI and 54 HIV-1-infected controls matched for age, duration of antiretroviral therapy, sex, smoking and no known cardiovascular disease. Levels of high-sensitivity C-reactive protein, soluble endothelial selectin, soluble vascular cell adhesion molecule, soluble intercellular adhesion molecule, matrix metalloprotease 9, myeloperoxidase, and plasminogen activator inhibitor 1 (PAI-1) were measured using a Luminex assay in plasma samples from routine visits both 12 and 2 months prior to the case patient's MI.RESULTS: The two groups had similar HIV characteristics and traditional cardiovascular risk factors. In univariate analysis, PAI-1 levels were associated with MI, whereas none of the other markers showed any association.In multivariate analyses adjusting for the D:A:D risk score, HIV viral load and high-sensitivity C-reactive protein, PAI-1 levels in the highest quartile were associated with a six to seven-fold increased risk of MI in both samples.CONCLUSION: High levels of PAI-1 were associated with risk of first-time MI in HIV-1-infected individuals independently of cardiovascular risk factors, HIV parameters and antiretroviral therapy. Therefore PAI-1 may be used for risk stratification and prediction of CHD, but further studies are needed.

KW - Adult

KW - Biological Markers

KW - C-Reactive Protein

KW - Case-Control Studies

KW - Cell Adhesion Molecules

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Matrix Metalloproteinase 9

KW - Middle Aged

KW - Myocardial Infarction

KW - Peroxidase

KW - Plasminogen Activator Inhibitor 1

KW - Risk Factors

KW - Selectins

KW - Vascular Cell Adhesion Molecule-1

KW - Viral Load

U2 - 10.1097/QAD.0000000000000247

DO - 10.1097/QAD.0000000000000247

M3 - Journal article

C2 - 24566095

VL - 28

SP - 1171

EP - 1179

JO - AIDS

JF - AIDS

SN - 1350-2840

IS - 8

ER -

ID: 137618902