Oxyntomodulin: actions and role in diabetes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.
Originalsprog | Engelsk |
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Tidsskrift | Peptides |
Vol/bind | 100 |
Sider (fra-til) | 48-53 |
Antal sider | 6 |
ISSN | 0196-9781 |
DOI | |
Status | Udgivet - 2018 |
ID: 189765037