Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

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Tanja Xenia Pedersen, Marie Madsen, Nanna Maria Junker Nielsen, Christina Christoffersen, Jonas Vikeså, Susanne Bro, Anna Hultgårdh-Nilsson, Lars Bo Nielsen

Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.
OriginalsprogEngelsk
TidsskriftCardiovascular Research
Vol/bind98
Udgave nummer3
Sider (fra-til)352-9
Antal sider8
ISSN0008-6363
DOI
StatusUdgivet - 1 jun. 2013

ID: 45810489