Normal Values and Reference Ranges for the Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate: The Copenhagen City Heart Study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: The ratio of transmitral early filling velocity to early diastolic strain rate (E/e'sr) has recently emerged as a measure of left ventricular filling pressure. Reference values are needed for this new parameter for it to be used clinically. Methods: Healthy participants from a prospective general population study, the Fifth Copenhagen City Heart Study, were assessed to establish reference values for E/e'sr derived from two-dimensional speckle-tracking echocardiography. The prevalence of abnormal E/e'sr was assessed in participants with cardiovascular risk factors or specific diseases. Results: The population comprised 1,623 healthy participants (median age, 45; interquartile range, 32-56; 61% female). The upper reference limit for E/e'sr in the population was 79.6 cm. Following multivariable adjustment, male participants exhibited significantly higher E/e'sr than female participants (upper reference limit for male participants, 83.7 cm; for female participants, 76.5 cm). For both sexes, E/e'sr increased in a curvilinear fashion with age such that the largest increases in E/e'sr were observed in participants >45 years. In the entire CCHS5 population with E/e'sr available (n = 3,902), increasing age, body mass index, systolic blood pressure, male sex, estimated glomerular filtration rate, and diabetes were associated with E/e'sr (all P <.05). Total cholesterol was associated with a less steep increase in E/e'sr. Abnormal E/e'sr was seldomly observed in participants with normal diastolic function but became more frequent in participants with increasing grades of diastolic dysfunction (normal, mild, moderate, severe [abnormal E/e'sr for each grade: 4.4% vs 20.0% vs 16.2% vs 55.6%, respectively]). Conclusion: The E/e'sr differs between sexes and is age dependent such that E/e'sr increases with advancing age. Therefore, we established sex- and age-stratified reference values for E/e'sr.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Society of Echocardiography |
Vol/bind | 30 |
Udgave nummer | 11 |
Sider (fra-til) | 1204-1212 |
ISSN | 0894-7317 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Funding: The Copenhagen City Heart Study was funded by the Danish Heart Foundation . M.H.L. was funded by a research grant from Herlev and Gentofte Hospital and the Danish Heart Foundation (grant no. 21-R149-A10082-22194 ). T.B.S. was funded by Herlev and Gentofte Hospital , Fondsbørsvekselerer Henry Hansen og Hustrus Hovedlegat , the Lundbeck Foundation , and the Novo Nordisk Foundation .
Funding Information:
Disclosure statement: T.B.S. is a Steering Committee member of the Amgen-financed GALACTIC-HF trial; is on the Steering Committee of the Boston Scientific financed LUX-Dx TRENDS trial; is on the Advisory Board of Sanofi Pasteur and Amgen; has received speaker honoraria from Novartis and Sanofi Pasteur; and has received research grants from GE Healthcare Sanofi Pasteur AstraZeneca, and Novo Nordisk .
Publisher Copyright:
© 2023 American Society of Echocardiography
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