N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.

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Standard

N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. / Balázs, R; Hack, N; Jørgensen, Ole Steen; Cotman, C W.

I: Neuroscience Letters, Bind 101, Nr. 3, 1989, s. 241-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Balázs, R, Hack, N, Jørgensen, OS & Cotman, CW 1989, 'N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.', Neuroscience Letters, bind 101, nr. 3, s. 241-6.

APA

Balázs, R., Hack, N., Jørgensen, O. S., & Cotman, C. W. (1989). N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neuroscience Letters, 101(3), 241-6.

Vancouver

Balázs R, Hack N, Jørgensen OS, Cotman CW. N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neuroscience Letters. 1989;101(3):241-6.

Author

Balázs, R ; Hack, N ; Jørgensen, Ole Steen ; Cotman, C W. / N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. I: Neuroscience Letters. 1989 ; Bind 101, Nr. 3. s. 241-6.

Bibtex

@article{70e507007da011dd81b0000ea68e967b,
title = "N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.",
abstract = "The survival of cerebellar granule cells in culture is promoted by chronic exposure to N-methyl-D-aspartate (NMDA). The effect is due to the stimulation of 'conventional' NMDA receptor-ionophore complex: it is concentration dependent, voltage dependent and blocked by the selective antagonists D-2-amino-5-phosphonovalerate, D-2-amino-7-phosphonoheptanoate, dextromethorphan and (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imin emaleate (MK 801). The most potent antagonist tested was MK-801. In contrast, non-selective antagonists, including kynurenate, were much less effective. Further, the trophic effect of NMDA is not reproduced by ibotenate or quinolinate at the concentration range tested. It could also be shown that glutamate released into the culture medium is responsible for limited cell survival in the absence of NMDA.",
author = "R Bal{\'a}zs and N Hack and J{\o}rgensen, {Ole Steen} and Cotman, {C W}",
note = "Keywords: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter",
year = "1989",
language = "English",
volume = "101",
pages = "241--6",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.

AU - Balázs, R

AU - Hack, N

AU - Jørgensen, Ole Steen

AU - Cotman, C W

N1 - Keywords: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter

PY - 1989

Y1 - 1989

N2 - The survival of cerebellar granule cells in culture is promoted by chronic exposure to N-methyl-D-aspartate (NMDA). The effect is due to the stimulation of 'conventional' NMDA receptor-ionophore complex: it is concentration dependent, voltage dependent and blocked by the selective antagonists D-2-amino-5-phosphonovalerate, D-2-amino-7-phosphonoheptanoate, dextromethorphan and (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imin emaleate (MK 801). The most potent antagonist tested was MK-801. In contrast, non-selective antagonists, including kynurenate, were much less effective. Further, the trophic effect of NMDA is not reproduced by ibotenate or quinolinate at the concentration range tested. It could also be shown that glutamate released into the culture medium is responsible for limited cell survival in the absence of NMDA.

AB - The survival of cerebellar granule cells in culture is promoted by chronic exposure to N-methyl-D-aspartate (NMDA). The effect is due to the stimulation of 'conventional' NMDA receptor-ionophore complex: it is concentration dependent, voltage dependent and blocked by the selective antagonists D-2-amino-5-phosphonovalerate, D-2-amino-7-phosphonoheptanoate, dextromethorphan and (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imin emaleate (MK 801). The most potent antagonist tested was MK-801. In contrast, non-selective antagonists, including kynurenate, were much less effective. Further, the trophic effect of NMDA is not reproduced by ibotenate or quinolinate at the concentration range tested. It could also be shown that glutamate released into the culture medium is responsible for limited cell survival in the absence of NMDA.

M3 - Journal article

C2 - 2549463

VL - 101

SP - 241

EP - 246

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 3

ER -

ID: 5941357