N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.

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Standard

N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia. / Diemer, N H; Johansen, Flemming Fryd; Jørgensen, M B.

I: Stroke, Bind 21, Nr. 11 Suppl, 1990, s. III39-42.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Diemer, NH, Johansen, FF & Jørgensen, MB 1990, 'N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.', Stroke, bind 21, nr. 11 Suppl, s. III39-42.

APA

Diemer, N. H., Johansen, F. F., & Jørgensen, M. B. (1990). N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia. Stroke, 21(11 Suppl), III39-42.

Vancouver

Diemer NH, Johansen FF, Jørgensen MB. N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia. Stroke. 1990;21(11 Suppl):III39-42.

Author

Diemer, N H ; Johansen, Flemming Fryd ; Jørgensen, M B. / N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia. I: Stroke. 1990 ; Bind 21, Nr. 11 Suppl. s. III39-42.

Bibtex

@article{090a86d05e1211dd8d9f000ea68e967b,
title = "N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.",
abstract = "The hippocampal lesion induced by cerebral ischemia has several excitotoxic features. Denervation of the ischemia-vulnerable pyramidal cells has a protective effect. Because most synapses are glutamatergic, administration of glutamate antagonists after ischemia also could be protective. Growing evidence now indicates that non-N-methyl-D-aspartate antagonists are more effective than N-methyl-D-aspartate antagonists in complete global ischemia. One explanation offered is that ischemia may sensitize pyramidal neurons so that {"}normal{"} postischemic synaptic activity induces lethal damage.",
author = "Diemer, {N H} and Johansen, {Flemming Fryd} and J{\o}rgensen, {M B}",
note = "Keywords: Animals; Brain Ischemia; Glutamates; Hippocampus; N-Methylaspartate",
year = "1990",
language = "English",
volume = "21",
pages = "III39--42",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams & Wilkins",
number = "11 Suppl",

}

RIS

TY - JOUR

T1 - N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.

AU - Diemer, N H

AU - Johansen, Flemming Fryd

AU - Jørgensen, M B

N1 - Keywords: Animals; Brain Ischemia; Glutamates; Hippocampus; N-Methylaspartate

PY - 1990

Y1 - 1990

N2 - The hippocampal lesion induced by cerebral ischemia has several excitotoxic features. Denervation of the ischemia-vulnerable pyramidal cells has a protective effect. Because most synapses are glutamatergic, administration of glutamate antagonists after ischemia also could be protective. Growing evidence now indicates that non-N-methyl-D-aspartate antagonists are more effective than N-methyl-D-aspartate antagonists in complete global ischemia. One explanation offered is that ischemia may sensitize pyramidal neurons so that "normal" postischemic synaptic activity induces lethal damage.

AB - The hippocampal lesion induced by cerebral ischemia has several excitotoxic features. Denervation of the ischemia-vulnerable pyramidal cells has a protective effect. Because most synapses are glutamatergic, administration of glutamate antagonists after ischemia also could be protective. Growing evidence now indicates that non-N-methyl-D-aspartate antagonists are more effective than N-methyl-D-aspartate antagonists in complete global ischemia. One explanation offered is that ischemia may sensitize pyramidal neurons so that "normal" postischemic synaptic activity induces lethal damage.

M3 - Journal article

C2 - 2237983

VL - 21

SP - III39-42

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 11 Suppl

ER -

ID: 5259394