Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.

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Standard

Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat. / Tønder, N; Sørensen, T; Johansen, Flemming Fryd; Zimmer, J.

I: Acta Neurobiologiae Experimentalis, Bind 50, Nr. 4-5, 1990, s. 367-80.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tønder, N, Sørensen, T, Johansen, FF & Zimmer, J 1990, 'Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.', Acta Neurobiologiae Experimentalis, bind 50, nr. 4-5, s. 367-80.

APA

Tønder, N., Sørensen, T., Johansen, F. F., & Zimmer, J. (1990). Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat. Acta Neurobiologiae Experimentalis, 50(4-5), 367-80.

Vancouver

Tønder N, Sørensen T, Johansen FF, Zimmer J. Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat. Acta Neurobiologiae Experimentalis. 1990;50(4-5):367-80.

Author

Tønder, N ; Sørensen, T ; Johansen, Flemming Fryd ; Zimmer, J. / Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat. I: Acta Neurobiologiae Experimentalis. 1990 ; Bind 50, Nr. 4-5. s. 367-80.

Bibtex

@article{fa40b5b05e1211dd8d9f000ea68e967b,
title = "Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.",
abstract = "Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) grafting of suspensions of late fetal CA3 cells to one week old ibotenic acid lesions of the adult rat CA3--and (iii) grafting of suspensions of late fetal CA1 cells to one week old ischemic lesions of the adult rat CA1, we conclude that axon-sparing lesions of the mentioned types enhance the growth of adult host brain axons of the so called point-to-point type into neural grafts. We interpret these findings as the result of an improved capability of adult host brain axons to participate in the graft host interaxonal competition for synaptic sites in the developing neural grafts. At the same time an extensive growth of graft CA3 and CA1 axons into the host brain was demonstrated.",
author = "N T{\o}nder and T S{\o}rensen and Johansen, {Flemming Fryd} and J Zimmer",
note = "Keywords: Animals; Animals, Newborn; Axons; Brain Tissue Transplantation; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Pyramidal Tracts; Rats",
year = "1990",
language = "English",
volume = "50",
pages = "367--80",
journal = "Acta Neurobiologiae Experimentalis",
issn = "0065-1400",
publisher = "Polska Akademia Nauk Instytut Biologii Doswiadczalnej im. M. Nenckiego",
number = "4-5",

}

RIS

TY - JOUR

T1 - Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.

AU - Tønder, N

AU - Sørensen, T

AU - Johansen, Flemming Fryd

AU - Zimmer, J

N1 - Keywords: Animals; Animals, Newborn; Axons; Brain Tissue Transplantation; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Pyramidal Tracts; Rats

PY - 1990

Y1 - 1990

N2 - Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) grafting of suspensions of late fetal CA3 cells to one week old ibotenic acid lesions of the adult rat CA3--and (iii) grafting of suspensions of late fetal CA1 cells to one week old ischemic lesions of the adult rat CA1, we conclude that axon-sparing lesions of the mentioned types enhance the growth of adult host brain axons of the so called point-to-point type into neural grafts. We interpret these findings as the result of an improved capability of adult host brain axons to participate in the graft host interaxonal competition for synaptic sites in the developing neural grafts. At the same time an extensive growth of graft CA3 and CA1 axons into the host brain was demonstrated.

AB - Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) grafting of suspensions of late fetal CA3 cells to one week old ibotenic acid lesions of the adult rat CA3--and (iii) grafting of suspensions of late fetal CA1 cells to one week old ischemic lesions of the adult rat CA1, we conclude that axon-sparing lesions of the mentioned types enhance the growth of adult host brain axons of the so called point-to-point type into neural grafts. We interpret these findings as the result of an improved capability of adult host brain axons to participate in the graft host interaxonal competition for synaptic sites in the developing neural grafts. At the same time an extensive growth of graft CA3 and CA1 axons into the host brain was demonstrated.

M3 - Journal article

C2 - 2130655

VL - 50

SP - 367

EP - 380

JO - Acta Neurobiologiae Experimentalis

JF - Acta Neurobiologiae Experimentalis

SN - 0065-1400

IS - 4-5

ER -

ID: 5259416