Nasal DNA methylation at three CpG sites predicts childhood allergic disease

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Nasal DNA methylation at three CpG sites predicts childhood allergic disease. / van Breugel, Merlijn; Qi, Cancan; Xu, Zhongli; Pedersen, Casper Emil T.; Petoukhov, Ilya; Vonk, Judith M.; Gehring, Ulrike; Berg, Marijn; Bügel, Marnix; Carpaij, Orestes A.; Forno, Erick; Morin, Andréanne; Eliasen, Anders U.; Jiang, Yale; van den Berge, Maarten; Nawijn, Martijn C.; Li, Yang; Chen, Wei; Bont, Louis J.; Bønnelykke, Klaus; Celedón, Juan C.; Koppelman, Gerard H.; Xu, Cheng Jian.

I: Nature Communications, Bind 13, 7415, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

van Breugel, M, Qi, C, Xu, Z, Pedersen, CET, Petoukhov, I, Vonk, JM, Gehring, U, Berg, M, Bügel, M, Carpaij, OA, Forno, E, Morin, A, Eliasen, AU, Jiang, Y, van den Berge, M, Nawijn, MC, Li, Y, Chen, W, Bont, LJ, Bønnelykke, K, Celedón, JC, Koppelman, GH & Xu, CJ 2022, 'Nasal DNA methylation at three CpG sites predicts childhood allergic disease', Nature Communications, bind 13, 7415. https://doi.org/10.1038/s41467-022-35088-6

APA

van Breugel, M., Qi, C., Xu, Z., Pedersen, C. E. T., Petoukhov, I., Vonk, J. M., Gehring, U., Berg, M., Bügel, M., Carpaij, O. A., Forno, E., Morin, A., Eliasen, A. U., Jiang, Y., van den Berge, M., Nawijn, M. C., Li, Y., Chen, W., Bont, L. J., ... Xu, C. J. (2022). Nasal DNA methylation at three CpG sites predicts childhood allergic disease. Nature Communications, 13, [7415]. https://doi.org/10.1038/s41467-022-35088-6

Vancouver

van Breugel M, Qi C, Xu Z, Pedersen CET, Petoukhov I, Vonk JM o.a. Nasal DNA methylation at three CpG sites predicts childhood allergic disease. Nature Communications. 2022;13. 7415. https://doi.org/10.1038/s41467-022-35088-6

Author

van Breugel, Merlijn ; Qi, Cancan ; Xu, Zhongli ; Pedersen, Casper Emil T. ; Petoukhov, Ilya ; Vonk, Judith M. ; Gehring, Ulrike ; Berg, Marijn ; Bügel, Marnix ; Carpaij, Orestes A. ; Forno, Erick ; Morin, Andréanne ; Eliasen, Anders U. ; Jiang, Yale ; van den Berge, Maarten ; Nawijn, Martijn C. ; Li, Yang ; Chen, Wei ; Bont, Louis J. ; Bønnelykke, Klaus ; Celedón, Juan C. ; Koppelman, Gerard H. ; Xu, Cheng Jian. / Nasal DNA methylation at three CpG sites predicts childhood allergic disease. I: Nature Communications. 2022 ; Bind 13.

Bibtex

@article{efc6bdc9eb2a42b88ebdb1e6cb2be603,
title = "Nasal DNA methylation at three CpG sites predicts childhood allergic disease",
abstract = "Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of allergen-specific IgE. We hypothesize that a multi-omics model could accurately diagnose childhood allergic disease. We show that nasal DNA methylation has the strongest predictive power to diagnose childhood allergy, surpassing blood DNA methylation, genetic risk scores, and environmental factors. DNA methylation at only three nasal CpG sites classifies allergic disease in Dutch children aged 16 years well, with an area under the curve (AUC) of 0.86. This is replicated in Puerto Rican children aged 9–20 years (AUC 0.82). DNA methylation at these CpGs additionally detects allergic multimorbidity and symptomatic IgE sensitization. Using nasal single-cell RNA-sequencing data, these three CpGs associate with influx of T cells and macrophages that contribute to allergic inflammation. Our study suggests the potential of methylation-based allergy diagnosis.",
author = "{van Breugel}, Merlijn and Cancan Qi and Zhongli Xu and Pedersen, {Casper Emil T.} and Ilya Petoukhov and Vonk, {Judith M.} and Ulrike Gehring and Marijn Berg and Marnix B{\"u}gel and Carpaij, {Orestes A.} and Erick Forno and Andr{\'e}anne Morin and Eliasen, {Anders U.} and Yale Jiang and {van den Berge}, Maarten and Nawijn, {Martijn C.} and Yang Li and Wei Chen and Bont, {Louis J.} and Klaus B{\o}nnelykke and Celed{\'o}n, {Juan C.} and Koppelman, {Gerard H.} and Xu, {Cheng Jian}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-35088-6",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Nasal DNA methylation at three CpG sites predicts childhood allergic disease

AU - van Breugel, Merlijn

AU - Qi, Cancan

AU - Xu, Zhongli

AU - Pedersen, Casper Emil T.

AU - Petoukhov, Ilya

AU - Vonk, Judith M.

AU - Gehring, Ulrike

AU - Berg, Marijn

AU - Bügel, Marnix

AU - Carpaij, Orestes A.

AU - Forno, Erick

AU - Morin, Andréanne

AU - Eliasen, Anders U.

AU - Jiang, Yale

AU - van den Berge, Maarten

AU - Nawijn, Martijn C.

AU - Li, Yang

AU - Chen, Wei

AU - Bont, Louis J.

AU - Bønnelykke, Klaus

AU - Celedón, Juan C.

AU - Koppelman, Gerard H.

AU - Xu, Cheng Jian

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of allergen-specific IgE. We hypothesize that a multi-omics model could accurately diagnose childhood allergic disease. We show that nasal DNA methylation has the strongest predictive power to diagnose childhood allergy, surpassing blood DNA methylation, genetic risk scores, and environmental factors. DNA methylation at only three nasal CpG sites classifies allergic disease in Dutch children aged 16 years well, with an area under the curve (AUC) of 0.86. This is replicated in Puerto Rican children aged 9–20 years (AUC 0.82). DNA methylation at these CpGs additionally detects allergic multimorbidity and symptomatic IgE sensitization. Using nasal single-cell RNA-sequencing data, these three CpGs associate with influx of T cells and macrophages that contribute to allergic inflammation. Our study suggests the potential of methylation-based allergy diagnosis.

AB - Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of allergen-specific IgE. We hypothesize that a multi-omics model could accurately diagnose childhood allergic disease. We show that nasal DNA methylation has the strongest predictive power to diagnose childhood allergy, surpassing blood DNA methylation, genetic risk scores, and environmental factors. DNA methylation at only three nasal CpG sites classifies allergic disease in Dutch children aged 16 years well, with an area under the curve (AUC) of 0.86. This is replicated in Puerto Rican children aged 9–20 years (AUC 0.82). DNA methylation at these CpGs additionally detects allergic multimorbidity and symptomatic IgE sensitization. Using nasal single-cell RNA-sequencing data, these three CpGs associate with influx of T cells and macrophages that contribute to allergic inflammation. Our study suggests the potential of methylation-based allergy diagnosis.

U2 - 10.1038/s41467-022-35088-6

DO - 10.1038/s41467-022-35088-6

M3 - Journal article

C2 - 36456559

AN - SCOPUS:85143186071

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7415

ER -

ID: 335682635