Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State. / Lewis, Christopher T.A.; Ochala, Julien.

I: Physiology, Bind 38, Nr. 1, 2023, s. 3-9.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Lewis, CTA & Ochala, J 2023, 'Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State', Physiology, bind 38, nr. 1, s. 3-9. https://doi.org/10.1152/physiol.00018.2022

APA

Lewis, C. T. A., & Ochala, J. (2023). Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State. Physiology, 38(1), 3-9. https://doi.org/10.1152/physiol.00018.2022

Vancouver

Lewis CTA, Ochala J. Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State. Physiology. 2023;38(1):3-9. https://doi.org/10.1152/physiol.00018.2022

Author

Lewis, Christopher T.A. ; Ochala, Julien. / Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State. I: Physiology. 2023 ; Bind 38, Nr. 1. s. 3-9.

Bibtex

@article{52b8230f57ab4a0481f81764eaff6f8c,
title = "Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State",
abstract = "After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle resting state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulating the ATP demand in health and disease. Finally, we present current experimental drugs targeting myosin ATP consumption and how they can treat muscle diseases.",
keywords = "cardiac muscle, DRX, myosin, skeletal muscle, SRX",
author = "Lewis, {Christopher T.A.} and Julien Ochala",
note = "Publisher Copyright: {\textcopyright} 2023 Int. Union Physiol. Sci./Am. Physiol. Soc.",
year = "2023",
doi = "10.1152/physiol.00018.2022",
language = "English",
volume = "38",
pages = "3--9",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

AU - Lewis, Christopher T.A.

AU - Ochala, Julien

N1 - Publisher Copyright: © 2023 Int. Union Physiol. Sci./Am. Physiol. Soc.

PY - 2023

Y1 - 2023

N2 - After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle resting state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulating the ATP demand in health and disease. Finally, we present current experimental drugs targeting myosin ATP consumption and how they can treat muscle diseases.

AB - After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle resting state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulating the ATP demand in health and disease. Finally, we present current experimental drugs targeting myosin ATP consumption and how they can treat muscle diseases.

KW - cardiac muscle

KW - DRX

KW - myosin

KW - skeletal muscle

KW - SRX

U2 - 10.1152/physiol.00018.2022

DO - 10.1152/physiol.00018.2022

M3 - Review

C2 - 36067133

AN - SCOPUS:85141353260

VL - 38

SP - 3

EP - 9

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 1

ER -

ID: 331790383