Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 167 |
Udgave nummer | 6 |
Sider (fra-til) | 1206-17 |
Antal sider | 12 |
ISSN | 0007-1188 |
DOI | |
Status | Udgivet - nov. 2012 |
ID: 47965272