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Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions. / Rummel, Pia Cwarzko; Arfelt, K N; Baumann, L; Jenkins, T J; Thiele, S; Lüttichau, H R; Johnsen, A; Pease, J; Ghosh, S; Kolbeck, R; Rosenkilde, M M.
I:
British Journal of Pharmacology, Bind 167, Nr. 6, 11.2012, s. 1206-17.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Rummel, PC, Arfelt, KN, Baumann, L, Jenkins, TJ, Thiele, S, Lüttichau, HR, Johnsen, A, Pease, J, Ghosh, S, Kolbeck, R
& Rosenkilde, MM 2012, '
Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions',
British Journal of Pharmacology, bind 167, nr. 6, s. 1206-17.
https://doi.org/10.1111/j.1476-5381.2012.02076.xAPA
Rummel, P. C., Arfelt, K. N., Baumann, L., Jenkins, T. J., Thiele, S., Lüttichau, H. R., Johnsen, A., Pease, J., Ghosh, S., Kolbeck, R.
, & Rosenkilde, M. M. (2012).
Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.
British Journal of Pharmacology,
167(6), 1206-17.
https://doi.org/10.1111/j.1476-5381.2012.02076.xVancouver
Rummel PC, Arfelt KN, Baumann L, Jenkins TJ, Thiele S, Lüttichau HR o.a.
Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.
British Journal of Pharmacology. 2012 nov.;167(6):1206-17.
https://doi.org/10.1111/j.1476-5381.2012.02076.xAuthor
Rummel, Pia Cwarzko ; Arfelt, K N ; Baumann, L ; Jenkins, T J ; Thiele, S ; Lüttichau, H R ; Johnsen, A ; Pease, J ; Ghosh, S ; Kolbeck, R ; Rosenkilde, M M. / Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions. I: British Journal of Pharmacology. 2012 ; Bind 167, Nr. 6. s. 1206-17.
Bibtex
@article{c92ef0efd1e04c8eb10094d3c98880e0,
title = "Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions",
abstract = "Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.",
keywords = "Animals, Binding Sites, Binding, Competitive, COS Cells, Cercopithecus aethiops, Chemokine CCL1, Chemokines, CC, Ligands, Naphthalenes, Receptors, CCR8, Viral Proteins",
author = "Rummel, {Pia Cwarzko} and Arfelt, {K N} and L Baumann and Jenkins, {T J} and S Thiele and L{\"u}ttichau, {H R} and A Johnsen and J Pease and S Ghosh and R Kolbeck and Rosenkilde, {M M}",
note = "{\textcopyright} 2012 The Authors. British Journal of Pharmacology {\textcopyright} 2012 The British Pharmacological Society.",
year = "2012",
month = nov,
doi = "10.1111/j.1476-5381.2012.02076.x",
language = "English",
volume = "167",
pages = "1206--17",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "6",
}
RIS
TY - JOUR
T1 - Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions
AU - Rummel, Pia Cwarzko
AU - Arfelt, K N
AU - Baumann, L
AU - Jenkins, T J
AU - Thiele, S
AU - Lüttichau, H R
AU - Johnsen, A
AU - Pease, J
AU - Ghosh, S
AU - Kolbeck, R
AU - Rosenkilde, M M
N1 - © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
PY - 2012/11
Y1 - 2012/11
N2 - Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.
AB - Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.
KW - Animals
KW - Binding Sites
KW - Binding, Competitive
KW - COS Cells
KW - Cercopithecus aethiops
KW - Chemokine CCL1
KW - Chemokines, CC
KW - Ligands
KW - Naphthalenes
KW - Receptors, CCR8
KW - Viral Proteins
U2 - 10.1111/j.1476-5381.2012.02076.x
DO - 10.1111/j.1476-5381.2012.02076.x
M3 - Journal article
C2 - 22708643
VL - 167
SP - 1206
EP - 1217
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 6
ER -
