Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective

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Molecular Mechanisms of Facultative Heterochromatin Formation : An X-Chromosome Perspective. / Żylicz, Jan J; Heard, Edith.

I: Annual Review of Biochemistry, Bind 89, 20.06.2020, s. 255-282.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Żylicz, JJ & Heard, E 2020, 'Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective', Annual Review of Biochemistry, bind 89, s. 255-282. https://doi.org/10.1146/annurev-biochem-062917-012655

APA

Żylicz, J. J., & Heard, E. (2020). Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective. Annual Review of Biochemistry, 89, 255-282. https://doi.org/10.1146/annurev-biochem-062917-012655

Vancouver

Żylicz JJ, Heard E. Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective. Annual Review of Biochemistry. 2020 jun. 20;89:255-282. https://doi.org/10.1146/annurev-biochem-062917-012655

Author

Żylicz, Jan J ; Heard, Edith. / Molecular Mechanisms of Facultative Heterochromatin Formation : An X-Chromosome Perspective. I: Annual Review of Biochemistry. 2020 ; Bind 89. s. 255-282.

Bibtex

@article{49df64579cda4ebe8e5aeb447d0094f2,
title = "Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective",
abstract = "Facultative heterochromatin (fHC) concerns the developmentally regulated heterochromatinization of different regions of the genome and, in the case of the mammalian X chromosome and imprinted loci, of only one allele of a homologous pair. The formation of fHC participates in the timely repression of genes, by resisting strong trans activators. In this review, we discuss the molecular mechanisms underlying the establishment and maintenance of fHC in mammals using a mouse model. We focus on X-chromosome inactivation (XCI) as a paradigm for fHC but also relate it to genomic imprinting and homeobox (Hox) gene cluster repression. A vital role for noncoding transcription and/or transcripts emerges as the general principle of triggering XCI and canonical imprinting. However, other types of fHC are established through an unknown mechanism, independent of noncoding transcription (Hox clusters and noncanonical imprinting). We also extensively discuss polycomb-group repressive complexes (PRCs), which frequently play a vital role in fHC maintenance.",
author = "{\.Z}ylicz, {Jan J} and Edith Heard",
year = "2020",
month = jun,
day = "20",
doi = "10.1146/annurev-biochem-062917-012655",
language = "English",
volume = "89",
pages = "255--282",
journal = "Annual Review of Biochemistry",
issn = "0066-4154",
publisher = "Annual Reviews, inc.",

}

RIS

TY - JOUR

T1 - Molecular Mechanisms of Facultative Heterochromatin Formation

T2 - An X-Chromosome Perspective

AU - Żylicz, Jan J

AU - Heard, Edith

PY - 2020/6/20

Y1 - 2020/6/20

N2 - Facultative heterochromatin (fHC) concerns the developmentally regulated heterochromatinization of different regions of the genome and, in the case of the mammalian X chromosome and imprinted loci, of only one allele of a homologous pair. The formation of fHC participates in the timely repression of genes, by resisting strong trans activators. In this review, we discuss the molecular mechanisms underlying the establishment and maintenance of fHC in mammals using a mouse model. We focus on X-chromosome inactivation (XCI) as a paradigm for fHC but also relate it to genomic imprinting and homeobox (Hox) gene cluster repression. A vital role for noncoding transcription and/or transcripts emerges as the general principle of triggering XCI and canonical imprinting. However, other types of fHC are established through an unknown mechanism, independent of noncoding transcription (Hox clusters and noncanonical imprinting). We also extensively discuss polycomb-group repressive complexes (PRCs), which frequently play a vital role in fHC maintenance.

AB - Facultative heterochromatin (fHC) concerns the developmentally regulated heterochromatinization of different regions of the genome and, in the case of the mammalian X chromosome and imprinted loci, of only one allele of a homologous pair. The formation of fHC participates in the timely repression of genes, by resisting strong trans activators. In this review, we discuss the molecular mechanisms underlying the establishment and maintenance of fHC in mammals using a mouse model. We focus on X-chromosome inactivation (XCI) as a paradigm for fHC but also relate it to genomic imprinting and homeobox (Hox) gene cluster repression. A vital role for noncoding transcription and/or transcripts emerges as the general principle of triggering XCI and canonical imprinting. However, other types of fHC are established through an unknown mechanism, independent of noncoding transcription (Hox clusters and noncanonical imprinting). We also extensively discuss polycomb-group repressive complexes (PRCs), which frequently play a vital role in fHC maintenance.

U2 - 10.1146/annurev-biochem-062917-012655

DO - 10.1146/annurev-biochem-062917-012655

M3 - Journal article

C2 - 32259458

VL - 89

SP - 255

EP - 282

JO - Annual Review of Biochemistry

JF - Annual Review of Biochemistry

SN - 0066-4154

ER -

ID: 259565936