Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. / Vringer, Esmee; Heilig, Rosalie; Riley, Joel S; Black, Annabel; Cloix, Catherine; Skalka, George; Montes-Gómez, Alfredo E; Aguado, Aurore; Lilla, Sergio; Walczak, Henning; Gyrd-Hansen, Mads; Murphy, Daniel J; Huang, Danny T; Zanivan, Sara; Tait, Stephen Wg.
I: The EMBO Journal, Bind 43, Nr. 6, 2024, s. 904–930.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
AU - Vringer, Esmee
AU - Heilig, Rosalie
AU - Riley, Joel S
AU - Black, Annabel
AU - Cloix, Catherine
AU - Skalka, George
AU - Montes-Gómez, Alfredo E
AU - Aguado, Aurore
AU - Lilla, Sergio
AU - Walczak, Henning
AU - Gyrd-Hansen, Mads
AU - Murphy, Daniel J
AU - Huang, Danny T
AU - Zanivan, Sara
AU - Tait, Stephen Wg
N1 - © 2024. The Author(s).
PY - 2024
Y1 - 2024
N2 - Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability to elicit anti-tumour immunity. Nonetheless, how MOMP triggers inflammation and how the cell regulates this remains poorly defined. We find that upon MOMP, many proteins localised either to inner or outer mitochondrial membranes are ubiquitylated in a promiscuous manner. This extensive ubiquitylation serves to recruit the essential adaptor molecule NEMO, leading to the activation of pro-inflammatory NF-κB signalling. We show that disruption of mitochondrial outer membrane integrity through different means leads to the engagement of a similar pro-inflammatory signalling platform. Therefore, mitochondrial integrity directly controls inflammation, such that permeabilised mitochondria initiate NF-κB signalling.
AB - Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability to elicit anti-tumour immunity. Nonetheless, how MOMP triggers inflammation and how the cell regulates this remains poorly defined. We find that upon MOMP, many proteins localised either to inner or outer mitochondrial membranes are ubiquitylated in a promiscuous manner. This extensive ubiquitylation serves to recruit the essential adaptor molecule NEMO, leading to the activation of pro-inflammatory NF-κB signalling. We show that disruption of mitochondrial outer membrane integrity through different means leads to the engagement of a similar pro-inflammatory signalling platform. Therefore, mitochondrial integrity directly controls inflammation, such that permeabilised mitochondria initiate NF-κB signalling.
U2 - 10.1038/s44318-024-00044-1
DO - 10.1038/s44318-024-00044-1
M3 - Journal article
C2 - 38337057
VL - 43
SP - 904
EP - 930
JO - E M B O Journal
JF - E M B O Journal
SN - 0261-4189
IS - 6
ER -
ID: 382761260