Migraine and subsequent head and neck cancer: A nationwide population-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Li-Tzu Wang
  • Ping-Hao Chiang
  • Chi-Hsiang Chung
  • Mingyang Song
  • Ashina, Sait
  • Wu-Chien Chien
  • Kevin Sheng-Kai Ma

Objectives: The association of migraine with the risk of certain cancer has been reported. The aim of this pilot study was to examine the associations between migraine and the onset of head and neck cancers (HNC). Materials and Methods: A total of 1755 individuals were identified through a nationwide population-based cohort registry in Taiwan between 2000 and 2013. The primary end point variable was new-onset head and neck cancers in patients with migraine versus non-migraine controls. Cox proportional hazard regression was used to derive the risk of HNC. Subgroup analyses were performed to determine subpopulations at risk of migraine-associated HNC. Sub-outcome analyses were carried out to provide the subtypes of migraine-associated HNC. Propensity score matching was utilized to validate the findings. Results: A total of four patients out of 351 patients with migraine and seven out of 1404 non-migraine controls developed HNC. The incidence of HNC was higher in patients with migraine than that in non-migraine controls (108.93 vs. 48.77 per 100,000 person-years) (adjusted hazard ratio, aHR = 2.908, 95% CI = 0.808–10.469; p = 0.102). The risk of HNC in patients with migraine with aura (aHR = 5.454, 95% CI = 0.948–26.875; p = 0.264) and without aura (aHR = 2.777, 95% CI = 0.755–8.473; p = 0.118) was revealed. The incidence of non-nasopharyngeal HNC secondary to migraine (112.79 per 100,000 person-years) was higher than that of nasopharyngeal cancer secondary to migraine (105.33 per 100,000 person-years). Conclusion: A higher incidence of HNC was observed in a small sample of patients with migraine, especially in those with migraine with aura. Migraine-associated HNC included non-nasopharyngeal HNC. Studies with a larger sample are needed to confirm the finding of the high risk of HNC in people with migraine.

OriginalsprogEngelsk
TidsskriftOral Diseases
Vol/bind30
Udgave nummer4
Sider (fra-til)2122-2135
ISSN1354-523X
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
This work was supported in part by funding from the Taiwan Ministry of Science & Technology (MOST: 108‐2813‐C‐040‐040‐B to K. S. M. and 109‐2326‐B‐002‐016‐MY3 to L. T. W.), and a research grant from International Team for Implantology (ITI) (fund no. 1577_2021 to K. S. M.).

Publisher Copyright:
© 2023 Wiley Periodicals LLC.

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