Mechanical basis and topological routes to cell elimination
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Mechanical basis and topological routes to cell elimination. / Monfared, Siavash; Ravichandran, Guruswami; Andrade, Jose; Doostmohammadi, Amin.
I: eLife, Bind 12, 82435, 18.04.2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Mechanical basis and topological routes to cell elimination
AU - Monfared, Siavash
AU - Ravichandran, Guruswami
AU - Andrade, Jose
AU - Doostmohammadi, Amin
PY - 2023/4/18
Y1 - 2023/4/18
N2 - Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remains largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards fivefold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.
AB - Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remains largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards fivefold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.
KW - epithelial cells
KW - cell extrusion
KW - collective cell migration
KW - defects in liquid crystals
KW - mechanobiology
KW - biophysics
KW - Other
KW - CONTACT INHIBITION
KW - DEFECTS
KW - DYNAMICS
KW - ANISOTROPY
KW - MIGRATION
KW - DIVISION
KW - STRESS
KW - FORCE
U2 - 10.7554/eLife.82435
DO - 10.7554/eLife.82435
M3 - Journal article
C2 - 37070647
VL - 12
JO - eLife
JF - eLife
SN - 2050-084X
M1 - 82435
ER -
ID: 346047952