Measurement of total risk of spontaneous abortion: the virtue of conditional risk estimation.
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Measurement of total risk of spontaneous abortion: the virtue of conditional risk estimation. / Modvig, J; Schmidt, L; Damsgaard, M T.
I: American Journal of Epidemiology, Bind 132, Nr. 6, 1990, s. 1021-38.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Measurement of total risk of spontaneous abortion: the virtue of conditional risk estimation.
AU - Modvig, J
AU - Schmidt, L
AU - Damsgaard, M T
N1 - Keywords: Abortion, Induced; Abortion, Spontaneous; Adult; Female; Gestational Age; Humans; Maternal Age; Models, Statistical; Pregnancy; Risk Factors
PY - 1990
Y1 - 1990
N2 - The concepts, methods, and problems of measuring spontaneous abortion risk are reviewed. The problems touched on include the process of pregnancy verification, the changes in risk by gestational age and maternal age, and the presence of induced abortions. Methods used in studies of spontaneous abortion risk include biochemical assays as well as life table technique, although the latter appears in two different forms. The consequences of using either of these are discussed. It is concluded that no study design so far is appropriate for measuring the total risk of spontaneous abortion from early conception to the end of the 27th week. It is proposed that pregnancy may be considered to consist of two or three specific periods and that different study designs should concentrate on measuring the conditional risk within each period. A careful estimate using this principle leads to an estimate of total risk of spontaneous abortion of 0.33.
AB - The concepts, methods, and problems of measuring spontaneous abortion risk are reviewed. The problems touched on include the process of pregnancy verification, the changes in risk by gestational age and maternal age, and the presence of induced abortions. Methods used in studies of spontaneous abortion risk include biochemical assays as well as life table technique, although the latter appears in two different forms. The consequences of using either of these are discussed. It is concluded that no study design so far is appropriate for measuring the total risk of spontaneous abortion from early conception to the end of the 27th week. It is proposed that pregnancy may be considered to consist of two or three specific periods and that different study designs should concentrate on measuring the conditional risk within each period. A careful estimate using this principle leads to an estimate of total risk of spontaneous abortion of 0.33.
M3 - Journal article
C2 - 2260534
VL - 132
SP - 1021
EP - 1038
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 6
ER -
ID: 4748009