MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

MDMA-assisted psychotherapy for PTSD : Growing evidence for memory effects mediating treatment efficacy. / Sarmanlu, Mesud; Kuypers, Kim P.C.; Vizeli, Patrick; Kvamme, Timo L.

I: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Bind 128, 110843, 2024.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Sarmanlu, M, Kuypers, KPC, Vizeli, P & Kvamme, TL 2024, 'MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy', Progress in Neuro-Psychopharmacology and Biological Psychiatry, bind 128, 110843. https://doi.org/10.1016/j.pnpbp.2023.110843

APA

Sarmanlu, M., Kuypers, K. P. C., Vizeli, P., & Kvamme, T. L. (2024). MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 128, [110843]. https://doi.org/10.1016/j.pnpbp.2023.110843

Vancouver

Sarmanlu M, Kuypers KPC, Vizeli P, Kvamme TL. MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2024;128. 110843. https://doi.org/10.1016/j.pnpbp.2023.110843

Author

Sarmanlu, Mesud ; Kuypers, Kim P.C. ; Vizeli, Patrick ; Kvamme, Timo L. / MDMA-assisted psychotherapy for PTSD : Growing evidence for memory effects mediating treatment efficacy. I: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2024 ; Bind 128.

Bibtex

@article{5c08d3ec49c24c35913b8c266cf448fd,
title = "MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy",
abstract = "The application of MDMA in conjunction with psychotherapy has in recent years seen a resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress disorder (PTSD). Clinical trials have shown promising safety and efficacy, but the mechanisms underlying this treatment form remain largely unestablished. This article explores recent preclinical and clinical evidence suggesting that the treatment's efficacy may be influenced by the mnemonic effects of MDMA. We review data on the effects of MDMA on fear extinction and fear reconsolidation and the utility of these processes for PTSD treatment. We corroborate our findings by incorporating research from cognitive psychology and psychopharmacology and offer recommendations for future research.",
keywords = "MDMA, memory, psychotherapy, PTSD, trauma",
author = "Mesud Sarmanlu and Kuypers, {Kim P.C.} and Patrick Vizeli and Kvamme, {Timo L.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2024",
doi = "10.1016/j.pnpbp.2023.110843",
language = "English",
volume = "128",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - MDMA-assisted psychotherapy for PTSD

T2 - Growing evidence for memory effects mediating treatment efficacy

AU - Sarmanlu, Mesud

AU - Kuypers, Kim P.C.

AU - Vizeli, Patrick

AU - Kvamme, Timo L.

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2024

Y1 - 2024

N2 - The application of MDMA in conjunction with psychotherapy has in recent years seen a resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress disorder (PTSD). Clinical trials have shown promising safety and efficacy, but the mechanisms underlying this treatment form remain largely unestablished. This article explores recent preclinical and clinical evidence suggesting that the treatment's efficacy may be influenced by the mnemonic effects of MDMA. We review data on the effects of MDMA on fear extinction and fear reconsolidation and the utility of these processes for PTSD treatment. We corroborate our findings by incorporating research from cognitive psychology and psychopharmacology and offer recommendations for future research.

AB - The application of MDMA in conjunction with psychotherapy has in recent years seen a resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress disorder (PTSD). Clinical trials have shown promising safety and efficacy, but the mechanisms underlying this treatment form remain largely unestablished. This article explores recent preclinical and clinical evidence suggesting that the treatment's efficacy may be influenced by the mnemonic effects of MDMA. We review data on the effects of MDMA on fear extinction and fear reconsolidation and the utility of these processes for PTSD treatment. We corroborate our findings by incorporating research from cognitive psychology and psychopharmacology and offer recommendations for future research.

KW - MDMA

KW - memory

KW - psychotherapy

KW - PTSD

KW - trauma

U2 - 10.1016/j.pnpbp.2023.110843

DO - 10.1016/j.pnpbp.2023.110843

M3 - Review

C2 - 37611653

AN - SCOPUS:85169834077

VL - 128

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 0278-5846

M1 - 110843

ER -

ID: 378825096