MCT1 helps brown fat suck up succinate
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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MCT1 helps brown fat suck up succinate. / Lund, Jens; Isidor, Marie Sophie; Gerhart-Hines, Zachary.
I: Nature Metabolism, Bind 6, 2024, s. 387–388.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - MCT1 helps brown fat suck up succinate
AU - Lund, Jens
AU - Isidor, Marie Sophie
AU - Gerhart-Hines, Zachary
N1 - Publisher Copyright: © Springer Nature Limited 2024.
PY - 2024
Y1 - 2024
N2 - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.
AB - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.
U2 - 10.1038/s42255-024-00979-z
DO - 10.1038/s42255-024-00979-z
M3 - Letter
C2 - 38378995
AN - SCOPUS:85185932267
VL - 6
SP - 387
EP - 388
JO - Nature Metabolism
JF - Nature Metabolism
SN - 2522-5812
ER -
ID: 386156310