Mass-spectrometric exploration of proteome structure and function
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Mass-spectrometric exploration of proteome structure and function. / Aebersold, Ruedi; Mann, Matthias.
I: Nature, Bind 537, Nr. 7620, 15.09.2016, s. 347-55.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mass-spectrometric exploration of proteome structure and function
AU - Aebersold, Ruedi
AU - Mann, Matthias
N1 - AR2016
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights into the composition, structure, function and control of the proteome, shedding light on complex biological processes and phenotypes.
AB - Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights into the composition, structure, function and control of the proteome, shedding light on complex biological processes and phenotypes.
KW - Journal Article
U2 - 10.1038/nature19949
DO - 10.1038/nature19949
M3 - Journal article
C2 - 27629641
VL - 537
SP - 347
EP - 355
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7620
ER -
ID: 165940141