Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation: A Danish Nationwide Register Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation : A Danish Nationwide Register Study. / Tønnesen, Jacob; Ruwald, Martin H.; Pallisgaard, Jannik; Rasmussen, Peter Vibe; Johannessen, Arne; Hansen, Jim; Worck, Rene H.; Zörner, Christopher R.; Riis-Vestergaard, Lise; Middelfart, Charlotte; Sørensen, Samuel K.; Sattler, Stefan; Gislason, Gunnar; Hansen, Morten Lock.

I: Journal of the American Heart Association, Bind 13, Nr. 7, e032722, 2024.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Tønnesen, J, Ruwald, MH, Pallisgaard, J, Rasmussen, PV, Johannessen, A, Hansen, J, Worck, RH, Zörner, CR, Riis-Vestergaard, L, Middelfart, C, Sørensen, SK, Sattler, S, Gislason, G & Hansen, ML 2024, 'Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation: A Danish Nationwide Register Study', Journal of the American Heart Association, bind 13, nr. 7, e032722. https://doi.org/10.1161/JAHA.123.032722

APA

Tønnesen, J., Ruwald, M. H., Pallisgaard, J., Rasmussen, P. V., Johannessen, A., Hansen, J., Worck, R. H., Zörner, C. R., Riis-Vestergaard, L., Middelfart, C., Sørensen, S. K., Sattler, S., Gislason, G., & Hansen, M. L. (2024). Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation: A Danish Nationwide Register Study. Journal of the American Heart Association, 13(7), [e032722]. https://doi.org/10.1161/JAHA.123.032722

Vancouver

Tønnesen J, Ruwald MH, Pallisgaard J, Rasmussen PV, Johannessen A, Hansen J o.a. Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation: A Danish Nationwide Register Study. Journal of the American Heart Association. 2024;13(7). e032722. https://doi.org/10.1161/JAHA.123.032722

Author

Tønnesen, Jacob ; Ruwald, Martin H. ; Pallisgaard, Jannik ; Rasmussen, Peter Vibe ; Johannessen, Arne ; Hansen, Jim ; Worck, Rene H. ; Zörner, Christopher R. ; Riis-Vestergaard, Lise ; Middelfart, Charlotte ; Sørensen, Samuel K. ; Sattler, Stefan ; Gislason, Gunnar ; Hansen, Morten Lock. / Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation : A Danish Nationwide Register Study. I: Journal of the American Heart Association. 2024 ; Bind 13, Nr. 7.

Bibtex

@article{37f29baa58474ebea259eef3346861c5,
title = "Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation: A Danish Nationwide Register Study",
abstract = "BACKGROUND: Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients with atrial fibrillation to ablation, delaying a potential subsequent ablation. However, delaying ablation may affect ablation outcomes. We sought to investigate the impact of duration from diagnosis to ablation on the risk of atrial fibrillation recurrence and adverse events. METHODS AND RESULTS: Using Danish nationwide registries, all patients with first-time ablation for atrial fibrillation were identified and included from 2010 to 2018. Patients were divided into 4 groups by diagnosis-to-ablation time: <1.0 year (early ablation), 1.0 to 1.9 years, 2.0 to 2.9 years, and >2.9 years (late ablation). The primary end point was atrial fibrillation recurrence after the 90-day blanking period, defined by admission for atrial fibrillation, cardioversions, use of antiarrhythmic drugs, or repeat atrial fibrillation ablations. The secondary end point was a composite end point of heart failure, ischemic stroke, or death, and each event individually. The study cohort consisted of 7705 patients. The 5-year cumulative incidence of atrial fibrillation recurrence in the 4 groups was 42.9%, 54.8%, 55.9%, and 58.4%, respectively. Hazard ratios were 1.20 (95% CI, 1.07-1.35), 1.29 (95% CI, 1.13-1.47), and 1.40 (95% CI, 1.28-1.53), respectively, with the early ablation group as reference. The hazard ratio for the combined secondary end point was 1.22 (95% CI, 1.04-1.44) in the late ablation group compared with the early ablation group. CONCLUSIONS: In patients undergoing ablation for atrial fibrillation, early ablation was associated with a significantly lower risk of atrial fibrillation recurrence. Furthermore, the associated risk of heart failure, ischemic stroke, or death was significantly lower in early-compared with late-ablation patients.",
keywords = "ablation, atrial fibrillation, diagnosis‐to‐ablation time, recurrence of atrial fibrillation",
author = "Jacob T{\o}nnesen and Ruwald, {Martin H.} and Jannik Pallisgaard and Rasmussen, {Peter Vibe} and Arne Johannessen and Jim Hansen and Worck, {Rene H.} and Z{\"o}rner, {Christopher R.} and Lise Riis-Vestergaard and Charlotte Middelfart and S{\o}rensen, {Samuel K.} and Stefan Sattler and Gunnar Gislason and Hansen, {Morten Lock}",
year = "2024",
doi = "10.1161/JAHA.123.032722",
language = "English",
volume = "13",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Lower Recurrence Rates of Atrial Fibrillation and MACE Events After Early Compared to Late Ablation

T2 - A Danish Nationwide Register Study

AU - Tønnesen, Jacob

AU - Ruwald, Martin H.

AU - Pallisgaard, Jannik

AU - Rasmussen, Peter Vibe

AU - Johannessen, Arne

AU - Hansen, Jim

AU - Worck, Rene H.

AU - Zörner, Christopher R.

AU - Riis-Vestergaard, Lise

AU - Middelfart, Charlotte

AU - Sørensen, Samuel K.

AU - Sattler, Stefan

AU - Gislason, Gunnar

AU - Hansen, Morten Lock

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients with atrial fibrillation to ablation, delaying a potential subsequent ablation. However, delaying ablation may affect ablation outcomes. We sought to investigate the impact of duration from diagnosis to ablation on the risk of atrial fibrillation recurrence and adverse events. METHODS AND RESULTS: Using Danish nationwide registries, all patients with first-time ablation for atrial fibrillation were identified and included from 2010 to 2018. Patients were divided into 4 groups by diagnosis-to-ablation time: <1.0 year (early ablation), 1.0 to 1.9 years, 2.0 to 2.9 years, and >2.9 years (late ablation). The primary end point was atrial fibrillation recurrence after the 90-day blanking period, defined by admission for atrial fibrillation, cardioversions, use of antiarrhythmic drugs, or repeat atrial fibrillation ablations. The secondary end point was a composite end point of heart failure, ischemic stroke, or death, and each event individually. The study cohort consisted of 7705 patients. The 5-year cumulative incidence of atrial fibrillation recurrence in the 4 groups was 42.9%, 54.8%, 55.9%, and 58.4%, respectively. Hazard ratios were 1.20 (95% CI, 1.07-1.35), 1.29 (95% CI, 1.13-1.47), and 1.40 (95% CI, 1.28-1.53), respectively, with the early ablation group as reference. The hazard ratio for the combined secondary end point was 1.22 (95% CI, 1.04-1.44) in the late ablation group compared with the early ablation group. CONCLUSIONS: In patients undergoing ablation for atrial fibrillation, early ablation was associated with a significantly lower risk of atrial fibrillation recurrence. Furthermore, the associated risk of heart failure, ischemic stroke, or death was significantly lower in early-compared with late-ablation patients.

AB - BACKGROUND: Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients with atrial fibrillation to ablation, delaying a potential subsequent ablation. However, delaying ablation may affect ablation outcomes. We sought to investigate the impact of duration from diagnosis to ablation on the risk of atrial fibrillation recurrence and adverse events. METHODS AND RESULTS: Using Danish nationwide registries, all patients with first-time ablation for atrial fibrillation were identified and included from 2010 to 2018. Patients were divided into 4 groups by diagnosis-to-ablation time: <1.0 year (early ablation), 1.0 to 1.9 years, 2.0 to 2.9 years, and >2.9 years (late ablation). The primary end point was atrial fibrillation recurrence after the 90-day blanking period, defined by admission for atrial fibrillation, cardioversions, use of antiarrhythmic drugs, or repeat atrial fibrillation ablations. The secondary end point was a composite end point of heart failure, ischemic stroke, or death, and each event individually. The study cohort consisted of 7705 patients. The 5-year cumulative incidence of atrial fibrillation recurrence in the 4 groups was 42.9%, 54.8%, 55.9%, and 58.4%, respectively. Hazard ratios were 1.20 (95% CI, 1.07-1.35), 1.29 (95% CI, 1.13-1.47), and 1.40 (95% CI, 1.28-1.53), respectively, with the early ablation group as reference. The hazard ratio for the combined secondary end point was 1.22 (95% CI, 1.04-1.44) in the late ablation group compared with the early ablation group. CONCLUSIONS: In patients undergoing ablation for atrial fibrillation, early ablation was associated with a significantly lower risk of atrial fibrillation recurrence. Furthermore, the associated risk of heart failure, ischemic stroke, or death was significantly lower in early-compared with late-ablation patients.

KW - ablation

KW - atrial fibrillation

KW - diagnosis‐to‐ablation time

KW - recurrence of atrial fibrillation

U2 - 10.1161/JAHA.123.032722

DO - 10.1161/JAHA.123.032722

M3 - Journal article

C2 - 38533962

AN - SCOPUS:85189751718

VL - 13

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 7

M1 - e032722

ER -

ID: 388946525